Top

BMC Cardiovascular Disorders

Published in:

Open Access 01-12-2015 | Research article

Serum S-100β and NSE levels after off-pump versus on-pump coronary artery bypass graft surgery

Authors: Lei Zheng, Qing-Ming Fan, Zhen-Yu Wei

Published in: BMC Cardiovascular Disorders | Issue 1/2015

Abstract

Background

We aimed to evaluate serum levels of S-100 beta (S-100β) and neuron specific enolase (NSE) in patients with coronary heart disease (CHD) after off-pump versus on-pump coronary artery bypass graft (CABG) surgery.

Methods

The PubMed (~2013) and the Chinese Biomedical Database (CBM) (1982 ~ 2013) were searched without language restrictions. After extraction of relevant data from selected studies, meta-analyses were conducted using STATA software (Version 12.0, Stata Corporation, College Station, Texas USA). Possible sources of heterogeneity were examined through univariate and multivariate meta-regression analyses and verified by Monte Carlo Simulation.

Results

Eleven studies with a total of 411 CHD patients met the inclusion criteria. Our meta-analysis showed no significant difference in serum S-100β and NSE levels between the on-pump group and the off-pump group before surgery. In the on-pump group, there was a significant difference in serum S-100β levels of CHD patients between before and after surgery, especially within the first 24 h after surgery. Furthermore, in the on-pump group, there was a significant difference in serum NSE levels of CHD patients between before and after surgery, particularly at 0 h after surgery. In the off-pump group, there was an obvious difference in serum S-100β levels between before and after surgery, especially within 24 h after surgery. Our results also demonstrated that serum S-100β and NSE levels of CHD patients in the on-pump group were significantly higher than those of patients in the off-pump group, especially within 24 h after surgery.

Conclusions

Our findings provide empirical evidence that off-pump and on-pump CABG surgeries may increase serum S-100β and NSE levels in CHD patients, which was most prominent within 24 h after on-pump CABG surgery.

Gaziano TA, Bitton A, Anand S, Abrahams-Gessel S, Murphy A. Growing epidemic of coronary heart disease in low- and middle-income countries. Curr Probl Cardiol. 2010;35(2):72–115.PubMedPubMedCentral

Odegaard AO. Coronary heart disease: what hope for the developing world? Heart. 2013;99(17):1227–9.PubMed

Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Borden WB, et al. Heart disease and stroke statistics–2013 update: a report from the American Heart Association. Circulation. 2013;127(1):e6–e245.PubMed

Serruys PW, Morice MC, Kappetein AP, Colombo A, Holmes DR, Mack MJ, et al. Percutaneous coronary intervention versus coronary-artery bypass grafting for severe coronary artery disease. N Engl J Med. 2009;360(10):961–72.PubMed

Ho PM, Bryson CL, Rumsfeld JS. Medication adherence: its importance in cardiovascular outcomes. Circulation. 2009;119(23):3028–35.PubMed

ElBardissi AW, Aranki SF, Sheng S, O'Brien SM, Greenberg CC, Gammie JS. Trends in isolated coronary artery bypass grafting: an analysis of the Society of Thoracic Surgeons adult cardiac surgery database. J Thorac Cardiovasc Surg. 2012;143(2):273–81.PubMed

Lamy A, Devereaux PJ, Prabhakaran D, Taggart DP, Hu S, Paolasso E, et al. Off-pump or on-pump coronary-artery bypass grafting at 30 days. N Engl J Med. 2012;366(16):1489–97.PubMed

Palmerini T, Biondi-Zoccai G, Riva DD, Mariani A, Savini C, Di Eusanio M, et al. Risk of stroke with percutaneous coronary intervention compared with on-pump and off-pump coronary artery bypass graft surgery: Evidence from a comprehensive network meta-analysis. Am Heart J. 2013;165(6):910–7. e914.PubMed

Selnes OA, Gottesman RF, Grega MA, Baumgartner WA, Zeger SL, McKhann GM. Cognitive and neurologic outcomes after coronary-artery bypass surgery. N Engl J Med. 2012;366(3):250–7.PubMed

10.

Kennedy ED, Choy KC, Alston RP, Chen S, Farhan-Alanie MM, Anderson J, et al. Cognitive outcome after on- and off-pump coronary artery bypass grafting surgery: a systematic review and meta-analysis. J Cardiothorac Vasc Anesth. 2013;27(2):253–65.PubMed

11.

Dabrowski W, Rzecki Z, Czajkowski M, Pilat J, Wacinski P, Kotlinska E, et al. Volatile anesthetics reduce biochemical markers of brain injury and brain magnesium disorders in patients undergoing coronary artery bypass graft surgery. J Cardiothorac Vasc Anesth. 2012;26(3):395–402.PubMed

12.

Yuan SM. Biomarkers of cerebral injury in cardiac surgery. Anadolu Kardiyol Derg. 2014;14(7):638–45.PubMed

13.

Astrand R, Unden J, Romner B. Clinical use of the calcium-binding S100B protein. Methods Mol Biol. 2013;963:373–84.PubMed

14.

Seco M, Edelman JJ, Wilson MK, Bannon PG, Vallely MP. Serum biomarkers of neurologic injury in cardiac operations. Ann Thorac Surg. 2012;94(3):1026–33.PubMed

15.

Sorci G, Bianchi R, Riuzzi F, Tubaro C, Arcuri C, Giambanco I, Donato R: S100B Protein, A Damage-Associated Molecular Pattern Protein in the Brain and Heart, and Beyond. Cardiovasc Psychiatry Neurol 2010, 2010; PMID: 20827421.

16.

Donato R, Cannon BR, Sorci G, Riuzzi F, Hsu K, Weber DJ, et al. Functions of S100 proteins. Curr Mol Med. 2013;13(1):24–57.PubMedPubMedCentral

17.

Beharier O, Kahn J, Shusterman E, Sheiner E. S100B - a potential biomarker for early detection of neonatal brain damage following asphyxia. J Matern Fetal Neonatal Med. 2012;25(9):1523–8.PubMed

18.

Michetti F, Corvino V, Geloso MC, Lattanzi W, Bernardini C, Serpero L, et al. The S100B protein in biological fluids: more than a lifelong biomarker of brain distress. J Neurochem. 2012;120(5):644–59.PubMed

19.

Yee KM, Ross-Cisneros FN, Lee JG, Da Rosa AB, Salomao SR, Berezovsky A, et al. Neuron-specific enolase is elevated in asymptomatic carriers of Leber's hereditary optic neuropathy. Invest Ophthalmol Vis Sci. 2012;53(10):6389–92.PubMedPubMedCentral

20.

Streitburger DP, Arelin K, Kratzsch J, Thiery J, Steiner J, Villringer A, et al. Validating serum S100B and neuron-specific enolase as biomarkers for the human brain - a combined serum, gene expression and MRI study. PLoS One. 2012;7(8), e43284.PubMedPubMedCentral

21.

Kobayashi J, Tashiro T, Ochi M, Yaku H, Watanabe G, Satoh T, et al. Early outcome of a randomized comparison of off-pump and on-pump multiple arterial coronary revascularization. Circulation. 2005;112(9 Suppl):I338–43.PubMed

22.

Bayram H, Hidiroglu M, Cetin L, Kucuker A, Iriz E, Uguz E, et al. Comparing S-100 beta protein levels and neurocognitive functions between patients undergoing on-pump and off-pump coronary artery bypass grafting. J Surg Res. 2013;182(2):198–202.PubMed

23.

Bonacchi M, Prifti E, Maiani M, Bartolozzi F, Di Eusanio M, Leacche M. Does off-pump coronary revascularization reduce the release of the cerebral markers, S-100beta and NSE? Heart Lung Circ. 2006;15(5):314–9.PubMed

24.

Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol. 2010;25(9):603–5.PubMed

25.

Zintzaras E, Ioannidis JP. HEGESMA: genome search meta-analysis and heterogeneity testing. Bioinformatics. 2005;21(18):3672–3.PubMed

26.

Zintzaras E, Ioannidis JP. Heterogeneity testing in meta-analysis of genome searches. Genet Epidemiol. 2005;28(2):123–37.PubMed

27.

Peters JL, Sutton AJ, Jones DR, Abrams KR, Rushton L. Comparison of two methods to detect publication bias in meta-analysis. JAMA. 2006;295(6):676–80.PubMed

28.

Huizenga HM, Visser I, Dolan CV. Testing overall and moderator effects in random effects meta-regression. Br J Math Stat Psychol. 2011;64(Pt 1):1–19.PubMed

29.

Jackson D, White IR, Riley RD. Quantifying the impact of between-study heterogeneity in multivariate meta-analyses. Stat Med. 2012;31(29):3805–20.PubMedPubMedCentral

30.

van Boven WJ, Morariu A, Salzberg SP, Gerritsen WB, Waanders FG, Korse TC, et al. Impact of different surgical strategies on perioperative protein S100beta release in elderly patients undergoing coronary artery bypass grafting. Innovations (Phila). 2013;8(3):230–6.

31.

Zhai YJ, Wang XL, Ji SY, Liu YR. Brain injuries in patients during cornonary artery bypass graft with or without cardiopulmonary bypass. Academic J Guangzhou Med Col. 2008;36(5):13–5.

32.

Yan XZ, Yang SY, Sun ZL, Huang FJ, Zhang DG, Xiang DK, et al. Off-pump coronary artery bypass grafting and neuronal injury. Guizhou Med J. 2002;26(6):483–5.

33.

Tian LQ, Cheng ZY, Li XH, Liu C. Effects of on-pump and off-pump coronary artery bypass grafting on plasma neuron specific enolase and S100 protein levels. Chin J Practical Nerv Dis. 2012;15(1):17–9.

34.

Liu JT, Li HY, He GX, Wang SB, Pu RF, Zhou F. The change and meaning of serum s100β protein during CABG with or without extracorporeal circulation. Chin J Extracorporeal Circulation. 2007;5(2):81–3. 120.

35.

Hong T, Wen DX, Hang YN. Effects of off-pump and on-pump on cerebral neurologic injuries in elder patients undergoing coronary artery bypass grafting. Jiangsu Med J. 2008;34(2):117–9.

36.

Hong F, Peng JM, Zhang RX, Chen JP. Serum concentration of S100 -B protein in patients during CABG with or without cardiopulmonary bypass. Chin J Pathophysiol. 2007;23(7):1293–5.

37.

Guo XY, Luo AL, Yin YQ, Ren HZ, Ye TH, Huang YG, et al. Perioperative plasma concentrations of neuron-specific enolase and postoperative cognitive function in patients undergoing coronary artery bypass grafting surgery. Basic & Clin Med. 2005;25(10):934–7.

38.

Gao CQ, He T, Li BJ, Wang G, Li JC, Mu YL. Comparison of cerebral Injury in patients during coronary artery bypass graft without versus with cardiopulmonary bypass. Chin Circulation J. 2003;18(6):449–52.

39.

Iriz E, Kolbakir F, Akar H, Adam B, Keceligil HT. Comparison of hydroxyethyl starch and ringer lactate as a prime solution regarding S-100beta protein levels and informative cognitive tests in cerebral injury. Ann Thorac Surg. 2005;79(2):666–71.PubMed

40.

Berger RP, Pierce MC, Wisniewski SR, Adelson PD, Clark RS, Ruppel RA, et al. Neuron-specific enolase and S100B in cerebrospinal fluid after severe traumatic brain injury in infants and children. Pediatrics. 2002;109(2), E31.PubMed

41.

Kapural M, Krizanac-Bengez L, Barnett G, Perl J, Masaryk T, Apollo D, et al. Serum S-100beta as a possible marker of blood–brain barrier disruption. Brain Res. 2002;940(1–2):102–4.PubMed

42.

Mackensen GB, Ti LK, Phillips-Bute BG, Mathew JP, Newman MF, Grocott HP. Cerebral embolization during cardiac surgery: impact of aortic atheroma burden. Br J Anaesth. 2003;91(5):656–61.PubMed

43.

Schoenburg M, Kraus B, Muehling A, Taborski U, Hofmann H, Erhardt G, et al. The dynamic air bubble trap reduces cerebral microembolism during cardiopulmonary bypass. J Thorac Cardiovasc Surg. 2003;126(5):1455–60.PubMed

44.

Grocott HP, Arrowsmith JE. Serum S100 protein as a marker of cerebral damage during cardiac surgery. Br J Anaesth. 2001;86(2):289–90.PubMed

45.

Woertgen C, Rothoerl RD, Brawanski A. Neuron-specific enolase serum levels after controlled cortical impact injury in the rat. J Neurotrauma. 2001;18(5):569–73.PubMed

46.

Bowles BJ, Lee JD, Dang CR, Taoka SN, Johnson EW, Lau EM, et al. Coronary artery bypass performed without the use of cardiopulmonary bypass is associated with reduced cerebral microemboli and improved clinical results. Chest. 2001;119(1):25–30.PubMed

47.

Lee JD, Lee SJ, Tsushima WT, Yamauchi H, Lau WT, Popper J, et al. Benefits of off-pump bypass on neurologic and clinical morbidity: a prospective randomized trial. Ann Thorac Surg. 2003;76(1):18–25. discussion 25–16.PubMed

48.

Edwards JH, Huang DT. Using pump for bypass surgery–on-off-on again? Crit Care. 2010;14(5):319.PubMedPubMedCentral

49.

Velissaris T, Jonas MM, Ohri SK. Hemodynamic advantages of right heart decompression during off-pump surgery. Asian Cardiovasc Thorac Ann. 2010;18(1):17–21.PubMed

Title: Serum S-100β and NSE levels after off-pump versus on-pump coronary artery bypass graft surgery
Authors: Lei Zheng
Qing-Ming Fan
Zhen-Yu Wei
Publication date: 01-12-2015
Publisher: BioMed Central
Published in: BMC Cardiovascular Disorders / Issue 1/2015
Electronic ISSN: 1471-2261
DOI: https://doi.org/10.1186/s12872-015-0050-0

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

Watch now

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Serum S-100β and NSE levels after off-pump versus on-pump coronary artery bypass graft surgery

Abstract

Background

Methods

Results

Conclusions

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

Please log in to get access to this content

Other articles of this Issue 1/2015

The difference between Asian and Western in the effect of LDL-C lowering therapy on coronary atherosclerotic plaque: a meta-analysis report

Hypertension prevalence, awareness, treatment, and control, in male South Asian immigrants in the United Arab Emirates: a cross-sectional study

Acute cardiac injury events ≤30 days after laboratory-confirmed influenza virus infection among U.S. veterans, 2010–2012

Prevalence and risk factors of premature coronary artery disease in patients undergoing coronary angiography in Kurdistan, Iraq

Influence of glycemic control on gain in VO2 peak, in patients with type 2 diabetes enrolled in cardiac rehabilitation after an acute coronary syndrome. The prospective DARE study

Meta- analysis and meta-regression analysis of the associations between sex and the operative outcomes of carotid endarterectomy

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page