Focus on sepsis

go back to reference De Backer D, Cecconi M, Lipman J, Machado F, Myatra SN, Ostermann M, Perner A, Teboul JL, Vincent JL, Walley KR (2019) Challenges in the management of septic shock: a narrative review. Intensive Care Med 45:420–433CrossRef De Backer D, Cecconi M, Lipman J, Machado F, Myatra SN, Ostermann M, Perner A, Teboul JL, Vincent JL, Walley KR (2019) Challenges in the management of septic shock: a narrative review. Intensive Care Med 45:420–433CrossRef

go back to reference Hernandez G, Bellomo R, Bakker J (2019) The ten pitfalls of lactate clearance in sepsis. Intensive Care Med 45:82–85CrossRef Hernandez G, Bellomo R, Bakker J (2019) The ten pitfalls of lactate clearance in sepsis. Intensive Care Med 45:82–85CrossRef

go back to reference Zampieri FG, Aguiar FJ, Bozza FA, Salluh JIF, Soares M, Investigators OS (2019) Modulators of systemic inflammatory response syndrome presence in patients admitted to intensive care units with acute infection: a Bayesian network approach. Intensive Care Med 45:1156–1158CrossRef Zampieri FG, Aguiar FJ, Bozza FA, Salluh JIF, Soares M, Investigators OS (2019) Modulators of systemic inflammatory response syndrome presence in patients admitted to intensive care units with acute infection: a Bayesian network approach. Intensive Care Med 45:1156–1158CrossRef

go back to reference Laterre PF, Berry SM, Blemings A, Carlsen JE, Francois B, Graves T, Jacobsen K, Lewis RJ, Opal SM, Perner A, Pickkers P, Russell JA, Windelov NA, Yealy DM, Asfar P, Bestle MH, Muller G, Bruel C, Brule N, Decruyenaere J, Dive AM, Dugernier T, Krell K, Lefrant JY, Megarbane B, Mercier E, Mira JP, Quenot JP, Rasmussen BS, Thorsen-Meyer HC, Vander Laenen M, Vang ML, Vignon P, Vinatier I, Wichmann S, Wittebole X, Kjolbye AL, Angus DC, Investigators S-A (2019) Effect of selepressin vs placebo on ventilator- and vasopressor-free days in patients with septic shock: the SEPSIS-ACT randomized clinical trial. JAMA. https://doi.org/10.1001/jama.2019.14607 CrossRefPubMedPubMedCentral Laterre PF, Berry SM, Blemings A, Carlsen JE, Francois B, Graves T, Jacobsen K, Lewis RJ, Opal SM, Perner A, Pickkers P, Russell JA, Windelov NA, Yealy DM, Asfar P, Bestle MH, Muller G, Bruel C, Brule N, Decruyenaere J, Dive AM, Dugernier T, Krell K, Lefrant JY, Megarbane B, Mercier E, Mira JP, Quenot JP, Rasmussen BS, Thorsen-Meyer HC, Vander Laenen M, Vang ML, Vignon P, Vinatier I, Wichmann S, Wittebole X, Kjolbye AL, Angus DC, Investigators S-A (2019) Effect of selepressin vs placebo on ventilator- and vasopressor-free days in patients with septic shock: the SEPSIS-ACT randomized clinical trial. JAMA. https://​doi.​org/​10.​1001/​jama.​2019.​14607 CrossRefPubMedPubMedCentral

go back to reference Fujii T, Luethi N, Young PJ, Frei DR, Eastwood GM, French CJ, Deane AM, Shehabi Y, Hajjar LA, Oliveira G, Udy AA, Orford N, Edney SJ, Hunt AL, Judd HL, Bitker L, Cioccari L, Naorungroj T, Yanase F, Bates S, McGain F, Hudson EP, Al-Bassam W, Dwivedi DB, Peppin C, McCracken P, Orosz J, Bailey M, Bellomo R, Investigators VT (2020) Effect of vitamin C, hydrocortisone, and thiamine vs hydrocortisone alone on time alive and free of vasopressor support among patients with septic shock: the VITAMINS randomized clinical trial. JAMA. https://doi.org/10.1001/jama.2019.22176 CrossRefPubMed Fujii T, Luethi N, Young PJ, Frei DR, Eastwood GM, French CJ, Deane AM, Shehabi Y, Hajjar LA, Oliveira G, Udy AA, Orford N, Edney SJ, Hunt AL, Judd HL, Bitker L, Cioccari L, Naorungroj T, Yanase F, Bates S, McGain F, Hudson EP, Al-Bassam W, Dwivedi DB, Peppin C, McCracken P, Orosz J, Bailey M, Bellomo R, Investigators VT (2020) Effect of vitamin C, hydrocortisone, and thiamine vs hydrocortisone alone on time alive and free of vasopressor support among patients with septic shock: the VITAMINS randomized clinical trial. JAMA. https://​doi.​org/​10.​1001/​jama.​2019.​22176 CrossRefPubMed

go back to reference Seymour CW, Kennedy JN, Wang S, Chang CH, Elliott CF, Xu Z, Berry S, Clermont G, Cooper G, Gomez H, Huang DT, Kellum JA, Mi Q, Opal SM, Talisa V, van der Poll T, Visweswaran S, Vodovotz Y, Weiss JC, Yealy DM, Yende S, Angus DC (2019) Derivation, validation, and potential treatment implications of novel clinical phenotypes for sepsis. JAMA 321:2003–2017CrossRef Seymour CW, Kennedy JN, Wang S, Chang CH, Elliott CF, Xu Z, Berry S, Clermont G, Cooper G, Gomez H, Huang DT, Kellum JA, Mi Q, Opal SM, Talisa V, van der Poll T, Visweswaran S, Vodovotz Y, Weiss JC, Yealy DM, Yende S, Angus DC (2019) Derivation, validation, and potential treatment implications of novel clinical phenotypes for sepsis. JAMA 321:2003–2017CrossRef

go back to reference Komorowski M, Celi LA, Badawi O, Gordon AC, Faisal AA (2018) The Artificial Intelligence Clinician learns optimal treatment strategies for sepsis in intensive care. Nat Med 24:1716–1720CrossRef Komorowski M, Celi LA, Badawi O, Gordon AC, Faisal AA (2018) The Artificial Intelligence Clinician learns optimal treatment strategies for sepsis in intensive care. Nat Med 24:1716–1720CrossRef

go back to reference Geri G, Vignon P, Aubry A, Fedou AL, Charron C, Silva S, Repesse X, Vieillard-Baron A (2019) Cardiovascular clusters in septic shock combining clinical and echocardiographic parameters: a post hoc analysis. Intensive Care Med 45:657–667CrossRef Geri G, Vignon P, Aubry A, Fedou AL, Charron C, Silva S, Repesse X, Vieillard-Baron A (2019) Cardiovascular clusters in septic shock combining clinical and echocardiographic parameters: a post hoc analysis. Intensive Care Med 45:657–667CrossRef

go back to reference Russell JA (2019) Vasopressor therapy in critically ill patients with shock. Intensive Care Med 45:1503–1517CrossRef Russell JA (2019) Vasopressor therapy in critically ill patients with shock. Intensive Care Med 45:1503–1517CrossRef

go back to reference Venkatesh B, Khanna AK, Cohen J (2019) Less is more: catecholamine-sparing strategies in septic shock. Intensive Care Med 45:1810–1812CrossRef Venkatesh B, Khanna AK, Cohen J (2019) Less is more: catecholamine-sparing strategies in septic shock. Intensive Care Med 45:1810–1812CrossRef

go back to reference Nagendran M, Russell JA, Walley KR, Brett SJ, Perkins GD, Hajjar L, Mason AJ, Ashby D, Gordon AC (2019) Vasopressin in septic shock: an individual patient data meta-analysis of randomised controlled trials. Intensive Care Med 45:844–855CrossRef Nagendran M, Russell JA, Walley KR, Brett SJ, Perkins GD, Hajjar L, Mason AJ, Ashby D, Gordon AC (2019) Vasopressin in septic shock: an individual patient data meta-analysis of randomised controlled trials. Intensive Care Med 45:844–855CrossRef

go back to reference Antcliffe DB, Santhakumaran S, Orme RML, Ward JK, Al-Beidh F, O’Dea K, Perkins GD, Singer M, McAuley DF, Mason AJ, Cross M, Ashby D, Gordon AC (2019) Levosimendan in septic shock in patients with biochemical evidence of cardiac dysfunction: a subgroup analysis of the LeoPARDS randomised trial. Intensive Care Med 45:1392–1400CrossRef Antcliffe DB, Santhakumaran S, Orme RML, Ward JK, Al-Beidh F, O’Dea K, Perkins GD, Singer M, McAuley DF, Mason AJ, Cross M, Ashby D, Gordon AC (2019) Levosimendan in septic shock in patients with biochemical evidence of cardiac dysfunction: a subgroup analysis of the LeoPARDS randomised trial. Intensive Care Med 45:1392–1400CrossRef

go back to reference Young PJ, Bellomo R, Bernard GR, Niven DJ, Schortgen F, Saxena M, Beasley R, Weatherall M (2019) Fever control in critically ill adults. An individual patient data meta-analysis of randomised controlled trials. Intensive Care Med 45:468–476CrossRef Young PJ, Bellomo R, Bernard GR, Niven DJ, Schortgen F, Saxena M, Beasley R, Weatherall M (2019) Fever control in critically ill adults. An individual patient data meta-analysis of randomised controlled trials. Intensive Care Med 45:468–476CrossRef

go back to reference Shankar-Hari M, Fish M, Azoulay E (2020) Should we consider blocking the inhibitory immune checkpoint molecules for treating T cell exhaustion in sepsis? Intensive Care Med 46:119–121CrossRef Shankar-Hari M, Fish M, Azoulay E (2020) Should we consider blocking the inhibitory immune checkpoint molecules for treating T cell exhaustion in sepsis? Intensive Care Med 46:119–121CrossRef

go back to reference Hotchkiss RS, Colston E, Yende S, Crouser ED, Martin GS, Albertson T, Bartz RR, Brakenridge SC, Delano MJ, Park PK, Donnino MW, Tidswell M, Mayr FB, Angus DC, Coopersmith CM, Moldawer LL, Catlett IM, Girgis IG, Ye J, Grasela DM (2019) Immune checkpoint inhibition in sepsis: a Phase 1b randomized study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of nivolumab. Intensive Care Med 45:1360–1371CrossRef Hotchkiss RS, Colston E, Yende S, Crouser ED, Martin GS, Albertson T, Bartz RR, Brakenridge SC, Delano MJ, Park PK, Donnino MW, Tidswell M, Mayr FB, Angus DC, Coopersmith CM, Moldawer LL, Catlett IM, Girgis IG, Ye J, Grasela DM (2019) Immune checkpoint inhibition in sepsis: a Phase 1b randomized study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of nivolumab. Intensive Care Med 45:1360–1371CrossRef

go back to reference Schetz M, Bein T (2019) When more could be industry-driven: the case of the extracorporeal treatment of sepsis. Intensive Care Med 45:1622–1625CrossRef Schetz M, Bein T (2019) When more could be industry-driven: the case of the extracorporeal treatment of sepsis. Intensive Care Med 45:1622–1625CrossRef

go back to reference Kleinpell R, Blot S, Boulanger C, Fulbrook P, Blackwood B (2019) International critical care nursing considerations and quality indicators for the 2017 surviving sepsis campaign guidelines. Intensive Care Med 45:1663–1666CrossRef Kleinpell R, Blot S, Boulanger C, Fulbrook P, Blackwood B (2019) International critical care nursing considerations and quality indicators for the 2017 surviving sepsis campaign guidelines. Intensive Care Med 45:1663–1666CrossRef

go back to reference Mankowski RT, Yende S, Angus DC (2019) Long-term impact of sepsis on cardiovascular health. Intensive Care Med 45:78–81CrossRef Mankowski RT, Yende S, Angus DC (2019) Long-term impact of sepsis on cardiovascular health. Intensive Care Med 45:78–81CrossRef