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Behavioral and Brain Functions
Published in: Behavioral and Brain Functions 1/2017

Open Access 01-12-2017 | Research

Selective impairments of alerting and executive control in HIV-infected patients: evidence from attention network test

Authors: Yi-quan Wang, Yang Pan, Sheng Zhu, Yong-guang Wang, Zhi-hua Shen, Kai Wang

Published in: Behavioral and Brain Functions | Issue 1/2017

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Abstract

Background

Attention ability can be subdivided into three functionally independent networks, i.e., alerting network, orienting network, and executive network. Previous literature has documented that deficits in attention are a common consequence of HIV infection. However, the precise nature of deficits of attention in HIV-infected patients is poorly understood. Accordingly, the aim of the study was to identify whether the HIV-infected patients showed a specific attention network deficit or a general attentional impairment.

Methods

We investigated 27 HIV-infected patients and 31 normal controls with the Attention Network Test (ANT).

Results

The patients exhibited less efficient alerting network and executive network than controls. No significant difference was found in orienting network effect between groups. Our results also indicate a tendency for poorer efficiency on alerting attention and executive attention in patients with CD4 ≤ 200.

Conclusions

Our findings suggest that HIV-infected patients exhibited selective impairments of attention network of alerting and executive control. The link between lower CD4 T cell count and poorer attention network function imply the importance of starting antiretroviral therapy earlier to avoid irreversible neurocognitive impairment.
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Metadata
Title
Selective impairments of alerting and executive control in HIV-infected patients: evidence from attention network test
Authors
Yi-quan Wang
Yang Pan
Sheng Zhu
Yong-guang Wang
Zhi-hua Shen
Kai Wang
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Behavioral and Brain Functions / Issue 1/2017
Electronic ISSN: 1744-9081
DOI
https://doi.org/10.1186/s12993-017-0129-0

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