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European Archives of Psychiatry and Clinical Neuroscience

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Open Access 10-06-2023 | Schizophrenia | Original Paper

Schizophrenia polygenic risk score in psychosis proneness

Authors: Patricia Mas-Bermejo, Sergi Papiol, Marc Via, Paula Rovira, Pilar Torrecilla, Thomas R. Kwapil, Neus Barrantes-Vidal, Araceli Rosa

Published in: European Archives of Psychiatry and Clinical Neuroscience | Issue 8/2023

Abstract

Schizophrenia (SZ) is a complex disorder with a highly polygenic inheritance. It can be conceived as the extreme expression of a continuum of traits that are present in the general population often broadly referred to as schizotypy. However, it is still poorly understood how these traits overlap genetically with the disorder. We investigated whether polygenic risk for SZ is associated with these disorder-related phenotypes (schizotypy, psychotic-like experiences, and subclinical psychopathology) in a sample of 253 non-clinically identified participants. Polygenic risk scores (PRSs) were constructed based on the latest SZ genome-wide association study using the PRS-CS method. Their association with self-report and interview measures of SZ-related traits was tested. No association with either schizotypy or psychotic-like experiences was found. However, we identified a significant association with the Motor Change subscale of the Comprehensive Assessment of At-Risk Mental States (CAARMS) interview. Our results indicate that the genetic overlap of SZ with schizotypy and psychotic-like experiences is less robust than previously hypothesized. The relationship between high PRS for SZ and motor abnormalities could reflect neurodevelopmental processes associated with psychosis proneness and SZ.

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Title: Schizophrenia polygenic risk score in psychosis proneness
Authors: Patricia Mas-Bermejo
Sergi Papiol
Marc Via
Paula Rovira
Pilar Torrecilla
Thomas R. Kwapil
Neus Barrantes-Vidal
Araceli Rosa
Publication date: 10-06-2023
Publisher: Springer Berlin Heidelberg
Keyword: Schizophrenia
Published in: European Archives of Psychiatry and Clinical Neuroscience / Issue 8/2023
Print ISSN: 0940-1334
Electronic ISSN: 1433-8491
DOI: https://doi.org/10.1007/s00406-023-01633-7

At a glance: The STEP trials

Springer Medicine

Schizophrenia polygenic risk score in psychosis proneness

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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