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01-07-2019 | Sarcoidosis | Review Article

Small-fiber neuropathy definition, diagnosis, and treatment

Authors: Natalia Y. Basantsova, Anna A. Starshinova, Amir Dori, Yulia S. Zinchenko, Piotr K. Yablonskiy, Yehuda Shoenfeld

Published in: Neurological Sciences | Issue 7/2019

Abstract

In the last 30 years, improvement of diagnostic methods enabled routine evaluation of small A-delta and C nerve fibers impairment, which results with the clinical condition known as a small-fiber neuropathy (SFN). This syndrome develops as a result of metabolic, toxic, immune-mediated, or genetic factors. The main clinical features include neuropathic pain and autonomic disturbance, which are occasionally disclaimed due to outstanding fatigue, daily performance decline, anxiety, and depression. As clinical, neurological, nerve conduction, and electromyography studies are commonly normal, diagnosis often depends on the finding of decreased intra-epidermal density of nerve fibers, per skin biopsy. This review highlights the etiology, clinical, diagnostic aspects, and SFN treatment.

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Title: Small-fiber neuropathy definition, diagnosis, and treatment
Authors: Natalia Y. Basantsova
Anna A. Starshinova
Amir Dori
Yulia S. Zinchenko
Piotr K. Yablonskiy
Yehuda Shoenfeld
Publication date: 01-07-2019
Publisher: Springer International Publishing
Keywords: Sarcoidosis
Neuropathic Pain
Sarcoidosis
Published in: Neurological Sciences / Issue 7/2019
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-019-03871-x

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Small-fiber neuropathy definition, diagnosis, and treatment

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