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Japanese Journal of Ophthalmology
Published in: Japanese Journal of Ophthalmology 2/2021

01-03-2021 | Sarcoidosis | Clinical Investigation

Validation of systemic parameters for the diagnosis of ocular sarcoidosis

Authors: Kayo Suzuki, Kenichi Namba, Kazuomi Mizuuchi, Daiju Iwata, Takako Ito, Keitaro Hase, Nobuyoshi Kitaichi, Susumu Ishida

Published in: Japanese Journal of Ophthalmology | Issue 2/2021

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Abstract

Purpose

Ocular sarcoidosis is diagnosed based on suggestive intraocular findings and systemic investigations. In this study, we assessed the clinical usefulness of systemic parameters in the diagnosis of ocular sarcoidosis.

Study design

A retrospective study.

Methods

This study included 79 cases (19 men, 60 women) with ocular sarcoidosis who visited Hokkaido University Hospital from 2011 to 2015 and were followed up for more than one year. The control group was 91 cases of other uveitis (38 men, 53 women). All cases underwent blood examination for the measurement of angiotensin-converting enzyme (ACE), Krebs von den Lungen-6 (KL-6), soluble interleukin-2 receptor (sIL-2R), and calcium (Ca) levels. Bilateral hilar lymphadenopathy (BHL) was also examined by plain chest X-ray and contrasting chest computed tomography (CT).

Results

The sensitivity for sIL-2R (76.4%) was higher than for ACE (37.7%), KL-6 (26.3%), and Ca (11.8%), although all showed high specificity: ACE (97.5%), KL-6 (96.2%), sIL-2R (93.8%), and Ca (95.1%). From these results, the Youden index of sIL-2R (0.70) was higher than that of ACE (0.35), KL-6 (0.26), and Ca (0.07). Imaging tests revealed better detection of BHL by contrasting chest CT (82.7%) than by plain chest X-ray (29.5%).

Conclusion

The present findings indicate that the systemic parameters, particularly serum sIL-2R levels and BHL on contrasting chest CT, are useful biomarkers for the diagnosis of ocular sarcoidosis.
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Metadata
Title
Validation of systemic parameters for the diagnosis of ocular sarcoidosis
Authors
Kayo Suzuki
Kenichi Namba
Kazuomi Mizuuchi
Daiju Iwata
Takako Ito
Keitaro Hase
Nobuyoshi Kitaichi
Susumu Ishida
Publication date
01-03-2021
Publisher
Springer Japan
Published in
Japanese Journal of Ophthalmology / Issue 2/2021
Print ISSN: 0021-5155
Electronic ISSN: 1613-2246
DOI
https://doi.org/10.1007/s10384-020-00793-6

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