Published in:
01-08-2018 | ORIGINAL ARTICLE
Salicytamide: a New Anti-inflammatory Designed Drug Candidate
Authors:
Karen Marinho Maciel Guedes, Rosivaldo Santos Borges, Enéas Andrade Fontes-Júnior, Andressa Santa Brigida Silva, Luanna Melo Pereira Fernandes, Sabrina Carvalho Cartágenes, Ana Carla Godinho Pinto, Mallone Lopes Silva, Luana Melo Diogo Queiroz, José Luís Fernandes Vieira, Pergentino José Cunha Sousa, Cristiane Socorro Ferraz Maia
Published in:
Inflammation
|
Issue 4/2018
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Abstract
Salicytamide is a new drug developed through molecular modelling and rational drug design by the molecular association of paracetamol and salicylic acid. This study was conducted to assess the acute oral toxicity, antinociceptive, and antioedematogenic properties of salicytamide. Acute toxicity was based on the OECD 423 guidelines. Antinociceptive properties were investigated using the writhing, hot plate and formalin tests in Swiss mice. Antioedematogenic properties were evaluated using the carrageenan-induced paw oedema model and croton oil-induced dermatitis in Wistar rats. Salicytamide did not promote behavioural changes or animal deaths during acute oral toxicity evaluation. Furthermore, salicytamide exhibited peripheral antinociceptive activity as evidenced by the reduction in writhing behaviour (ED50 = 4.95 mg/kg) and licking time in the formalin test’s inflammatory phase. Also, salicytamide elicited central antinociceptive activity on both hot plate test and formalin test’s neurogenic phase. Additionally, salicytamide was effective in reducing carrageenan or croton oil-induced oedema formation. Overall, we have shown that salicytamide, proposed here as a new NSAID candidate, did not induce oral acute toxicity and elicited both peripheral antinociceptive effects (about 10–25 times more potent than its precursors in the writhing test) and antioedematogenic properties. Salicytamide also presented central antinociceptive activity, which seems to be mediated through opioid-independent mechanisms. These findings reveal salicytamide as a promising antinociceptive/antioedematogenic drug candidate.