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Maxillofacial Plastic and Reconstructive Surgery

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Open Access 01-12-2016 | Research

S100 and p65 expression are increased in the masseter muscle after botulinum toxin-A injection

Authors: Young-Wook Park, Seong-Gon Kim, You-Young Jo

Published in: Maxillofacial Plastic and Reconstructive Surgery | Issue 1/2016

Abstract

Background

The purpose of this study was to compare the expression levels of p65 and S100 in the rat masseter muscle after the injection of different concentrations of botulinum toxin-A (BTX-A).

Methods

We injected either 5 or 10 U of BTX-A into both masseter muscle of rats. As a control group, the same volume of saline was injected. After 14 days, the animals were sacrificed. Subsequently, a biopsy and immunohistochemical staining of the samples were performed using a p65 or S100 antibody.

Results

The cross-sectional area of each myofibril was significantly reduced by BTX-A injection (P < 0.001). The expression of p65 and S100 increased significantly with increasing concentrations of BTX-A (P < 0.001).

Conclusions

The injection of BTX-A into the masseter muscle induced muscle atrophy. Subsequently, p65 and S100 expression in myoblasts were increased for the protection of muscle cells.

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Title: S100 and p65 expression are increased in the masseter muscle after botulinum toxin-A injection
Authors: Young-Wook Park
Seong-Gon Kim
You-Young Jo
Publication date: 01-12-2016
Publisher: Springer Berlin Heidelberg
Published in: Maxillofacial Plastic and Reconstructive Surgery / Issue 1/2016
Electronic ISSN: 2288-8586
DOI: https://doi.org/10.1186/s40902-016-0079-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

S100 and p65 expression are increased in the masseter muscle after botulinum toxin-A injection

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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