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Maxillofacial Plastic and Reconstructive Surgery
Published in: Maxillofacial Plastic and Reconstructive Surgery 1/2016

Open Access 01-12-2016 | Research

Chitin-fibroin-hydroxyapatite membrane for guided bone regeneration: micro-computed tomography evaluation in a rat model

Authors: Young-jae Baek, Jung-Han Kim, Jae-Min Song, Sang-Yong Yoon, Hong-Sung Kim, Sang-Hun Shin

Published in: Maxillofacial Plastic and Reconstructive Surgery | Issue 1/2016

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Abstract

Background

In guided bone regeneration (GBR) technique, many materials have been used for improving biological effectiveness by adding on membranes. The new membrane which was constructed with chitin-fibroin-hydroxyapatite (CNF/HAP) was compared with a collagen membrane (Bio-Gide®) by means of micro-computed tomography.

Methods

Fifty-four rats were used in this study. A critical-sized (8 mm) bony defect was created in the calvaria with a trephine bur. The CNF/HAP membrane was prepared by thermally induced phase separation. In the experimental group (n = 18), the CNF/HAP membrane was used to cover the bony defect, and in the control group (n = 18), a resorbable collagen membrane (Bio-Gide®) was used. In the negative control group (n = 18), no membrane was used. In each group, six animals were euthanized at 2, 4, and 8 weeks after surgery. The specimens were analyzed using micro-CT.

Results

Bone volume (BV) and bone mineral density (BMD) of the new bone showed significant difference between the negative control group and membrane groups (P < 0.05). However, between two membranes, the difference was not significant.

Conclusions

The CNF/HAP membrane has significant effect on the new bone formation and has the potential to be applied for guided bone regeneration.
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Metadata
Title
Chitin-fibroin-hydroxyapatite membrane for guided bone regeneration: micro-computed tomography evaluation in a rat model
Authors
Young-jae Baek
Jung-Han Kim
Jae-Min Song
Sang-Yong Yoon
Hong-Sung Kim
Sang-Hun Shin
Publication date
01-12-2016
Publisher
Springer Berlin Heidelberg
Published in
Maxillofacial Plastic and Reconstructive Surgery / Issue 1/2016
Electronic ISSN: 2288-8586
DOI
https://doi.org/10.1186/s40902-016-0060-6

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