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01-04-2009 | Original Article

Role of Osteopontin in Calcification in Autoimmune Pancreatitis

Authors: Hiroki Takada, Takahiro Nakazawa, Hirotaka Ohara, Tomoaki Ando, Kazuki Hayashi, Itaru Naito, Fumihiro Okumura, Hajime Tanaka, Tamaki Yamada, Satoru Takahashi, Takashi Joh

Published in: Digestive Diseases and Sciences | Issue 4/2009

Abstract

Objectives The aim of the present study was to determine the potential for pancreatic calcification in autoimmune pancreatitis by investigating osteopontin and CD44 expression. Methods Human pancreatic tissues in normal pancreas, chronic pancreatitis, and autoimmune pancreatitis were obtained from the surgical specimens of 42 patients. Pancreatic tissues from male Wistar Bonn/Kobori rats were also used as an animal autoimmune pancreatitis model. Results The incidences of osteopontin expression in centroacinar cells in chronic pancreatitis with calcification and in autoimmune pancreatitis were significantly greater than that in normal pancreas (P < 0.05). Some cases of chronic pancreatitis and autoimmune pancreatitis expressed CD44 in centroacinar cells and ductal cells. In male Wistar Bonn/Kobori rats, the inflammatory area and percentage of osteopontin-CD44-positive cells increased with advancing age (P < 0.01 or 0.05). Conclusions These results suggest that autoimmune pancreatitis has the potential for pancreatic calcification over a long-term clinical course.

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Title: Role of Osteopontin in Calcification in Autoimmune Pancreatitis
Authors: Hiroki Takada
Takahiro Nakazawa
Hirotaka Ohara
Tomoaki Ando
Kazuki Hayashi
Itaru Naito
Fumihiro Okumura
Hajime Tanaka
Tamaki Yamada
Satoru Takahashi
Takashi Joh
Publication date: 01-04-2009
Publisher: Springer US
Published in: Digestive Diseases and Sciences / Issue 4/2009
Print ISSN: 0163-2116
Electronic ISSN: 1573-2568
DOI: https://doi.org/10.1007/s10620-008-0418-4

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