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International Journal of Colorectal Disease

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01-09-2018 | Review

Risk of secondary rectal cancer and colon cancer after radiotherapy for prostate cancer: a meta-analysis

Authors: Zhiguo Zhu, Shankun Zhao, Yangzhou Liu, Jiamin Wang, Lianmin Luo, Ermao Li, Chaofeng Zhang, Jintai Luo, Zhigang Zhao

Published in: International Journal of Colorectal Disease | Issue 9/2018

Abstract

Purpose

To investigate whether radiotherapy for prostate cancer increases the risk of therapy-related rectal cancer and colon cancer.

Methods

A systematic literature search was carried out using the Medline (PubMed), EMBASE, and the Cochrane Library to identify studies examining the association between radiotherapy for prostate cancer and secondary colorectal cancer (rectal cancer and colon cancer) published before March 19, 2018. The risk of second colorectal cancer after radiotherapy was summarized using unadjusted odds ratio (OR) and adjusted hazard ratio (HR) with their 95% confidence interval (CI). Subgroup and sensitivity analyses were conducted to detect potential bias and heterogeneity.

Results

After study selection, 16 reports were retrieved for analysis. When patients received radiotherapy compared with those unexposed to radiation, there was an increased risk of the rectal cancer (OR 1.37, 95%CI 1.01 to 1.85), but not colon cancer. According to adjusted HR, there was an increased risk of the rectal cancer (HR 1.64, 95%CI 1.39 to 1.94), and colon cancer (HR 1.33, 95%CI 1.02 to 1.76). The OR for rectal cancer showed an increased risk with longer latent period (5 years lag time versus 10 years lag time, OR: 1.56 versus 2.22). Brachytherapy had no association with second cancer across all analyses.

Conclusions

Radiotherapy was associated with an increased risk of subsequent rectal cancer compared with patients unexposed to radiation. Colon may be free from the damage of radiation. Brachytherapy had no association with second rectal cancer or colon cancer.

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Title: Risk of secondary rectal cancer and colon cancer after radiotherapy for prostate cancer: a meta-analysis
Authors: Zhiguo Zhu
Shankun Zhao
Yangzhou Liu
Jiamin Wang
Lianmin Luo
Ermao Li
Chaofeng Zhang
Jintai Luo
Zhigang Zhao
Publication date: 01-09-2018
Publisher: Springer Berlin Heidelberg
Published in: International Journal of Colorectal Disease / Issue 9/2018
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI: https://doi.org/10.1007/s00384-018-3114-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Risk of secondary rectal cancer and colon cancer after radiotherapy for prostate cancer: a meta-analysis

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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