Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Pituitary
Published in: Pituitary 2/2017

01-04-2017

Risk-adapted, long-term management in childhood-onset craniopharyngioma

Author: Hermann L. Müller

Published in: Pituitary | Issue 2/2017

Login to get access

Abstract

Purpose

This report is a review of findings on the diagnosis, treatment, clinical course, follow-up, and prognosis of craniopharyngioma patients with special regard to clinical trials and long-term management.

Methods

Literature search on Pubmed for paper published after 1994.

Results

Craniopharyngiomas are rare, embryonic malformations of the sellar/parasellar region with low histological grade. Clinical manifestations are related to increased intracranial pressure, visual impairment, and hypothalamic/pituitary deficiencies. If the tumor is favorably localized, therapy of choice is complete resection, with care taken to preserve hypothalamic and optic functions. In patients with unfavorable tumor location (i.e. involvement of hypothalamic areas), recommended therapy is limited hypothalamus-sparing surgical strategy followed by irradiation. Irradiation has proven effective in treatment of recurrences and progression. Surgical lesions and/or anatomical involvement of posterior hypothalamic areas can result in serious sequelae, mainly hypothalamic syndrome.

Conclusions

It is crucial that craniopharyngioma be managed as a frequently chronic disease, providing ongoing care of pediatric and adult patients’ by experienced multidisciplinary teams in the context of multicenter trials.
Literature
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
11.
Nielsen EH, Feldt-Rasmussen U, Poulsgaard L, Kristensen LO, Astrup J, Jorgensen JO, Bjerre P, Andersen M, Andersen C, Jorgensen J, Lindholm J, Laurberg P (2011) Incidence of craniopharyngioma in Denmark (n = 189) and estimated world incidence of craniopharyngioma in children and adults. J Neurooncol 104(3):755–763. doi:10.​1007/​s11060-011-0540-6 PubMedCrossRef
12.
13.
Muller-Scholden J, Lehrnbecher T, Muller HL, Bensch J, Hengen RH, Sorensen N, Stockhausen HB (2000) Radical surgery in a neonate with craniopharyngioma. Report of a case. Pediatr Neurosurg 33(5):265–269PubMedCrossRef
14.
15.
16.
Muller HL, Bueb K, Bartels U, Roth C, Harz K, Graf N, Korinthenberg R, Bettendorf M, Kuhl J, Gutjahr P, Sorensen N, Calaminus G (2001) Obesity after childhood craniopharyngioma–German multicenter study on pre-operative risk factors and quality of life. Klin Padiatr 213(4):244–249. doi:10.​1055/​s-2001-16855 PubMedCrossRef
17.
Muller HL, Heinrich M, Bueb K, Etavard-Gorris N, Gebhardt U, Kolb R, Sorensen N (2003) Perioperative dexamethasone treatment in childhood craniopharyngioma–influence on short-term and long-term weight gain. Exp Clin Endocrinol Diabetes 111(6):330–334. doi:10.​1055/​s-2003-42722 PubMedCrossRef
18.
Sklar CA (1994) Craniopharyngioma: endocrine abnormalities at presentation. Pediatr Neurosurg 21(Suppl 1):18–20PubMed
19.
20.
21.
Muller HL, Emser A, Faldum A, Bruhnken G, Etavard-Gorris N, Gebhardt U, Oeverink R, Kolb R, Sorensen N (2004) Longitudinal study on growth and body mass index before and after diagnosis of childhood craniopharyngioma. J Clin Endocrinol Metab 89(7):3298–3305. doi:10.​1210/​jc.​2003-031751 PubMedCrossRef
22.
Hoffmann A, Boekhoff S, Gebhardt U, Sterkenburg AS, Daubenbuchel AM, Eveslage M, Muller HL (2015) History before diagnosis in childhood craniopharyngioma: associations with initial presentation and long-term prognosis. Eur J Endocrinol 173(6):853–862. doi:10.​1530/​EJE-15-0709 PubMedCrossRef
23.
24.
Elowe-Gruau E, Beltrand J, Brauner R, Pinto G, Samara-Boustani D, Thalassinos C, Busiah K, Laborde K, Boddaert N, Zerah M, Alapetite C, Grill J, Touraine P, Sainte-Rose C, Polak M, Puget S (2013) Childhood craniopharyngioma: hypothalamus-sparing surgery decreases the risk of obesity. J Clin Endocrinol Metab 98(6):2376–2382. doi:10.​1210/​jc.​2012-3928 PubMedCrossRef
25.
Puget S, Garnett M, Wray A, Grill J, Habrand JL, Bodaert N, Zerah M, Bezerra M, Renier D, Pierre-Kahn A, Sainte-Rose C (2007) Pediatric craniopharyngiomas: classification and treatment according to the degree of hypothalamic involvement. J Neurosurg 106(1 Suppl):3–12. doi:10.​3171/​ped.​2007.​106.​1.​3 PubMed
26.
27.
Muller HL, Gebhardt U, Faldum A, Warmuth-Metz M, Pietsch T, Pohl F, Calaminus G, Sorensen N (2012) Xanthogranuloma, Rathke’s cyst, and childhood craniopharyngioma: results of prospective multinational studies of children and adolescents with rare sellar malformations. J Clin Endocrinol Metab 97(11):3935–3943. doi:10.​1210/​jc.​2012-2069 PubMedCrossRef
28.
Muller HL, Gebhardt U, Teske C, Faldum A, Zwiener I, Warmuth-Metz M, Pietsch T, Pohl F, Sorensen N, Calaminus G (2011) Post-operative hypothalamic lesions and obesity in childhood craniopharyngioma: results of the multinational prospective trial KRANIOPHARYNGEOM 2000 after 3-year follow-up. Eur J Endocrinol 165(1):17–24. doi:10.​1530/​EJE-11-0158 PubMedCrossRef
29.
Mallucci C, Pizer B, Blair J, Didi M, Doss A, Upadrasta S, Newman W, Avula S, Pettorini B (2012) Management of craniopharyngioma: the Liverpool experience following the introduction of the CCLG guidelines. Introducing a new risk assessment grading system. Childs Nerv Syst 28(8):1181–1192. doi:10.​1007/​s00381-012-1787-8 PubMedCrossRef
30.
31.
Van Gompel JJ, Nippoldt TB, Higgins DM, Meyer FB (2010) Magnetic resonance imaging-graded hypothalamic compression in surgically treated adult craniopharyngiomas determining postoperative obesity. Neurosurg Focus 28(4):E3. doi:10.​3171/​2010.​1.​FOCUS09303 PubMedCrossRef
32.
33.
34.
Sanford RA (1994) Craniopharyngioma: results of survey of the American Society of Pediatric Neurosurgery. Pediatr Neurosurg 21(Suppl 1):39–43PubMed
35.
36.
Hankinson TC, Palmeri NO, Williams SA, Torok MR, Serrano CA, Foreman NK, Handler MH, Liu AK (2013) Patterns of care for craniopharyngioma: survey of members of the american association of neurological surgeons. Pediatr Neurosurg 49(3):131–136. doi:10.​1159/​000357783 PubMedCrossRef
37.
Hoffmann A, Warmth-Metz M, Gebhardt U, Pietsch T, Pohl F, Kortmann RD, Calaminus G, Muller HL (2014) Childhood craniopharyngioma—changes of treatment strategies in the trials KRANIOPHARYNGEOM 2000/2007. Klin Padiatr 226(3):161–168. doi:10.​1055/​s-0034-1368785 PubMedCrossRef
38.
Rath SR, Lee S, Kotecha RS, Taylor M, Junckerstorff RC, Choong CS (2013) Childhood craniopharyngioma: 20-year institutional experience in Western Australia. J Paediatr Child Health 49(5):403–408. doi:10.​1111/​jpc.​12190 PubMedCrossRef
39.
Lo AC, Howard AF, Nichol A, Sidhu K, Abdulsatar F, Hasan H, Goddard K (2014) Long-term outcomes and complications in patients with craniopharyngioma: the British Columbia Cancer Agency experience. Int J Radiat Oncol Biol Phys 88(5):1011–1018. doi:10.​1016/​j.​ijrobp.​2014.​01.​019 PubMedCrossRef
40.
Zaidi HA, Chapple K, Little AS (2014) National treatment trends, complications, and predictors of in-hospital charges for the surgical management of craniopharyngiomas in adults from 2007 to 2011. Neurosurg Focus 37(5):E6. doi:10.​3171/​2014.​8.​FOCUS14366 PubMedCrossRef
41.
42.
43.
44.
45.
Ali ZS, Bailey RL, Daniels LB, Vakhshori V, Lewis DJ, Hossain AT, Sitterley KY, Lee JY, Storm PB, Heuer GG, Stein SC (2014) Comparative effectiveness of treatment options for pediatric craniopharyngiomas. J Neurosurg Pediatr 13(2):178–188. doi:10.​3171/​2013.​11.​PEDS1320 PubMedCrossRef
46.
Ogawa Y, Kawaguchi T, Tominaga T (2014) Outcome and mid-term prognosis after maximum and radical removal of craniopharyngiomas with the priority to the extended transsphenoidal approach–a single center experience. Clin Neurol Neurosurg 125:41–46. doi:10.​1016/​j.​clineuro.​2014.​07.​014 PubMedCrossRef
47.
48.
49.
Caldarelli M, Massimi L, Tamburrini G, Cappa M, Di Rocco C (2005) Long-term results of the surgical treatment of craniopharyngioma: the experience at the Policlinico Gemelli, Catholic University, Rome. Childs Nerv Syst 21(8–9):747–757. doi:10.​1007/​s00381-005-1186-5 PubMedCrossRef
50.
51.
52.
53.
54.
Jung TY, Jung S, Moon KS, Kim IY, Kang SS, Kim JH (2010) Endocrinological outcomes of pediatric craniopharyngiomas with anatomical pituitary stalk preservation: preliminary study. Pediatr Neurosurg 46(3):205–212. doi:10.​1159/​000318426 PubMedCrossRef
55.
Merchant TE, Kiehna EN, Sanford RA, Mulhern RK, Thompson SJ, Wilson MW, Lustig RH, Kun LE (2002) Craniopharyngioma: the St. Jude Children’s Research Hospital experience 1984–2001. Int J Radiat Oncol Biol Phys 53(3):533–542PubMedCrossRef
56.
Poretti A, Grotzer MA, Ribi K, Schonle E, Boltshauser E (2004) Outcome of craniopharyngioma in children: long-term complications and quality of life. Dev Med Child Neurol 46(4):220–229PubMedCrossRef
57.
Ahmet A, Blaser S, Stephens D, Guger S, Rutkas JT, Hamilton J (2006) Weight gain in craniopharyngioma—a model for hypothalamic obesity. J Pediatr Endocrinol Metab 19(2):121–127PubMedCrossRef
58.
Mortini P, Losa M, Pozzobon G, Barzaghi R, Riva M, Acerno S, Angius D, Weber G, Chiumello G, Giovanelli M (2011) Neurosurgical treatment of craniopharyngioma in adults and children: early and long-term results in a large case series. J Neurosurg 114(5):1350–1359. doi:10.​3171/​2010.​11.​JNS10670 PubMedCrossRef
59.
60.
Crom D, Smith D, Xiong Z, Onar A, Hudson M, Merchant T, Morris E (2010) Health status in long-term survivors of pediatric craniopharyngiomas. Am Assoc Neurosci Nurses 42(6):323–328CrossRef
61.
Geffner M, Lundberg M, Koltowska-Haggstrom M, Abs R, Verhelst J, Erfurth EM, Kendall-Taylor P, Price DA, Jonsson P, Bakker B (2004) Changes in height, weight, and body mass index in children with craniopharyngioma after three years of growth hormone therapy: analysis of KIGS (Pfizer International Growth Database). J Clin Endocrinol Metab 89(11):5435–5440. doi:10.​1210/​jc.​2004-0667 PubMedCrossRef
62.
Srinivasan S, Ogle GD, Garnett SP, Briody JN, Lee JW, Cowell CT (2004) Features of the metabolic syndrome after childhood craniopharyngioma. J Clin Endocrinol Metab 89(1):81–86PubMedCrossRef
63.
Matson DD (1964) Craniopharyngioma. Clin Neurosurg 10:14
64.
Fjalldal S, Holmer H, Rylander L, Elfving M, Ekman B, Osterberg K, Erfurth EM (2013) Hypothalamic involvement predicts cognitive performance and psychosocial health in long-term survivors of childhood craniopharyngioma. J Clin Endocrinol Metab 98(8):3253–3262. doi:10.​1210/​jc.​2013-2000 PubMedCrossRef
65.
66.
67.
68.
69.
70.
Muller HL, Gebhardt U, Schroder S, Pohl F, Kortmann RD, Faldum A, Zwiener I, Warmuth-Metz M, Pietsch T, Calaminus G, Kolb R, Wiegand C, Sorensen N (2010) Analyses of treatment variables for patients with childhood craniopharyngioma–results of the multicenter prospective trial KRANIOPHARYNGEOM 2000 after three years of follow-up. Horm Res Paediatr 73(3):175–180. doi:10.​1159/​000284358 PubMedCrossRef
71.
Roth CL, Eslamy H, Werny D, Elfers C, Shaffer ML, Pihoker C, Ojemann J, Dobyns WB (2015) Semiquantitative analysis of hypothalamic damage on MRI predicts risk for hypothalamic obesity. Obesity (Silver Spring) 23(6):1226–1233. doi:10.​1002/​oby.​21067 CrossRef
72.
73.
Sterkenburg AS, Hoffmann A, Gebhardt U, Warmuth-Metz M, Daubenbuchel AM, Muller HL (2015) Survival, hypothalamic obesity, and neuropsychological/psychosocial status after childhood-onset craniopharyngioma: newly reported long-term outcomes. Neuro Oncol 17(7):1029–1038. doi:10.​1093/​neuonc/​nov044 PubMedCrossRef
74.
75.
Cohen M, Syme C, McCrindle BW, Hamilton J (2013) Autonomic nervous system balance in children and adolescents with craniopharyngioma and hypothalamic obesity. Eur J Endocrinol 168(6):845–852. doi:10.​1530/​EJE-12-1082 PubMedCrossRef
76.
77.
Harz KJ, Muller HL, Waldeck E, Pudel V, Roth C (2003) Obesity in patients with craniopharyngioma: assessment of food intake and movement counts indicating physical activity. J Clin Endocrinol Metab 88(11):5227–5231PubMedCrossRef
78.
Muller HL, Handwerker G, Gebhardt U, Faldum A, Emser A, Kolb R, Sorensen N (2006) Melatonin treatment in obese patients with childhood craniopharyngioma and increased daytime sleepiness. Cancer Causes Control 17(4):583–589. doi:10.​1007/​s10552-005-9012-7 PubMedCrossRef
79.
Muller HL, Handwerker G, Wollny B, Faldum A, Sorensen N (2002) Melatonin secretion and increased daytime sleepiness in childhood craniopharyngioma patients. J Clin Endocrinol Metab 87(8):3993–3996PubMedCrossRef
80.
O’Gorman CS, Simoneau-Roy J, Pencharz P, MacFarlane J, MacLusky I, Narang I, Adeli K, Daneman D, Hamilton J (2010) Sleep-disordered breathing is increased in obese adolescents with craniopharyngioma compared with obese controls. J Clin Endocrinol Metab 95(5):2211–2218. doi:10.​1210/​jc.​2009-2003 PubMedCrossRef
81.
Muller HL, Muller-Stover S, Gebhardt U, Kolb R, Sorensen N, Handwerker G (2006) Secondary narcolepsy may be a causative factor of increased daytime sleepiness in obese childhood craniopharyngioma patients. J Pediatr Endocrinol Metab 19(Suppl 1):423–429PubMed
82.
Mason PW, Krawiecki N, Meacham LR (2002) The use of dextroamphetamine to treat obesity and hyperphagia in children treated for craniopharyngioma. Arch Pediatri Adolesc Med 156(9):887–892CrossRef
83.
84.
Roth CL (2011) Hypothalamic obesity in patients with craniopharyngioma: profound changes of several weight regulatory circuits. Front Endocrinol (Lausanne) 2:49. doi:10.​3389/​fendo.​2011.​00049
85.
Bomer I, Saure C, Caminiti C, Ramos JG, Zuccaro G, Brea M, Bravo M, Maza C (2015) Comparison of energy expenditure, body composition, metabolic disorders, and energy intake between obese children with a history of craniopharyngioma and children with multifactorial obesity. J Pediatr Endocrinol Metab 28(11–12):1305–1312. doi:10.​1515/​jpem-2015-0167 PubMed
86.
Holmer H, Pozarek G, Wirfalt E, Popovic V, Ekman B, Bjork J, Erfurth EM (2010) Reduced energy expenditure and impaired feeding-related signals but not high energy intake reinforces hypothalamic obesity in adults with childhood onset craniopharyngioma. J Clin Endocrinol Metab 95(12):5395–5402. doi:10.​1210/​jc.​2010-0993 PubMedCrossRef
87.
88.
89.
90.
91.
Roemmler-Zehrer J, Geigenberger V, Stormann S, Losa M, Crippa V, Otto B, Bidlingmaier M, Dimopoulou C, Stalla GK, Schopohl J (2014) Food intake regulating hormones in adult craniopharyngioma patients. Eur J Endocrinol 170(4):627–635. doi:10.​1530/​EJE-13-0832 PubMedCrossRef
92.
93.
Roth C, Wilken B, Hanefeld F, Schroter W, Leonhardt U (1998) Hyperphagia in children with craniopharyngioma is associated with hyperleptinaemia and a failure in the downregulation of appetite. Eur J Endocrinol 138(1):89–91PubMedCrossRef
94.
Hoffmann A, Bootsveld K, Gebhardt U, Daubenbuchel AM, Sterkenburg AS, Muller HL (2015) Nonalcoholic fatty liver disease and fatigue in long-term survivors of childhood-onset craniopharyngioma. Eur J Endocrinol 173(3):389–397. doi:10.​1530/​EJE-15-0422 PubMedCrossRef
95.
96.
97.
98.
99.
Zoicas F, Droste M, Mayr B, Buchfelder M, Schofl C (2013) GLP-1 analogues as a new treatment option for hypothalamic obesity in adults: report of nine cases. Eur J Endocrinol 168(5):699–706. doi:10.​1530/​EJE-12-0997 PubMedCrossRef
100.
Profka E, Giavoli C, Bergamaschi S, Ferrante E, Malchiodi E, Sala E, Verrua E, Rodari G, Filopanti M, Beck-Peccoz P, Spada A (2015) Analysis of short- and long-term metabolic effects of growth hormone replacement therapy in adult patients with craniopharyngioma and non-functioning pituitary adenoma. J Endocrinol Investig 38(4):413–420. doi:10.​1007/​s40618-014-0196-0 CrossRef
101.
Yuen KC, Koltowska-Haggstrom M, Cook DM, Fox JL, Jonsson PJ, Geffner ME, Abs R (2013) Clinical characteristics and effects of GH replacement therapy in adults with childhood-onset craniopharyngioma compared with those in adults with other causes of childhood-onset hypothalamic-pituitary dysfunction. Eur J Endocrinol 169(4):511–519. doi:10.​1530/​EJE-13-0280 PubMedCrossRef
102.
Lustig RH, Hinds PS, Ringwald-Smith K, Christensen RK, Kaste SC, Schreiber RE, Rai SN, Lensing SY, Wu S, Xiong X (2003) Octreotide therapy of pediatric hypothalamic obesity: a double-blind, placebo-controlled trial. J Clin Endocrinol Metab 88(6):2586–2592PubMedCrossRef
103.
Bretault M, Boillot A, Muzard L, Poitou C, Oppert JM, Barsamian C, Gatta B, Muller H, Weismann D, Rottembourg D, Inge T, Veyrie N, Carette C, Czernichow S (2013) Clinical review: bariatric surgery following treatment for craniopharyngioma: a systematic review and individual-level data meta-analysis. J Clin Endocrinol Metab 98(6):2239–2246. doi:10.​1210/​jc.​2012-4184 PubMedCrossRef
104.
Gatta B, Nunes ML, Bailacq-Auder C, Etchechoury L, Collet D, Tabarin A (2013) Is bariatric surgery really inefficient in hypothalamic obesity? Clin Endocrinol 78(4):636–638. doi:10.​1111/​cen.​12031 CrossRef
105.
Muller HL, Gebhardt U, Wessel V, Schroder S, Kolb R, Sorensen N, Maroske J, Hanisch E (2007) First experiences with laparoscopic adjustable gastric banding (LAGB) in the treatment of patients with childhood craniopharyngioma and morbid obesity. Klin Padiatr 219(6):323–325. doi:10.​1055/​s-2007-985848 PubMedCrossRef
106.
Muller HL, Gebhardt U, Maroske J, Hanisch E (2011) Long-term follow-up of morbidly obese patients with childhood craniopharyngioma after laparoscopic adjustable gastric banding (LAGB). Klin Padiatr 223(6):372–373. doi:10.​1055/​s-0031-1284420 PubMedCrossRef
107.
Schultes B, Ernst B, Schmid F, Thurnheer M (2009) Distal gastric bypass surgery for the treatment of hypothalamic obesity after childhood craniopharyngioma. Eur J Endocrinol 161(1):201–206. doi:10.​1530/​EJE-09-0079 PubMedCrossRef
108.
Rottembourg D, O’Gorman CS, Urbach S, Garneau PY, Langer JC, Van Vliet G, Hamilton J, Huot C (2009) Outcome after bariatric surgery in two adolescents with hypothalamic obesity following treatment of craniopharyngioma. J Pediatr Endocrinol Metab 22(9):867–872PubMedCrossRef
109.
Gump JM, Donson AM, Birks DK, Amani VM, Rao KK, Griesinger AM, Kleinschmidt-DeMasters BK, Johnston JM, Anderson RC, Rosenfeld A, Handler M, Gore L, Foreman N, Hankinson TC (2015) Identification of targets for rational pharmacological therapy in childhood craniopharyngioma. Acta Neuropathol Commun 3:30. doi:10.​1186/​s40478-015-0211-5 PubMedPubMedCentralCrossRef
110.
Sterkenburg AS, Hoffmann A, Gebhardt U, Waldeck E, Springer S, Muller HL (2014) Childhood craniopharyngioma with hypothalamic obesity-no long-term weight reduction due to rehabilitation programs. Klin Padiatr 226(6–7):344–350. doi:10.​1055/​s-0034-1387747 PubMed
111.
Hoffmann A, Postma FP, Sterkenburg AS, Gebhardt U, Muller HL (2015) Eating behavior, weight problems and eating disorders in 101 long-term survivors of childhood-onset craniopharyngioma. J Pediatr Endocrinol Metab 28(1–2):35–43. doi:10.​1515/​jpem-2014-0415 PubMed
112.
Roth CL, Aylward E, Liang O, Kleinhans NM, Pauley G, Schur EA (2012) Functional neuroimaging in craniopharyngioma: a useful tool to better understand hypothalamic obesity? Obes Facts 5(2):243–253. doi:10.​1159/​000338695 PubMedCrossRef
113.
Roemmler-Zehrer J, Geigenberger V, Stormann S, Ising M, Pfister H, Sievers C, Stalla GK, Schopohl J (2015) Specific behaviour, mood and personality traits may contribute to obesity in patients with craniopharyngioma. Clin Endocrinol 82(1):106–114. doi:10.​1111/​cen.​12523 CrossRef
114.
Kilday JP, Bartels U, Huang A, Barron M, Shago M, Mistry M, Zhukova N, Laperriere N, Dirks P, Hawkins C, Bouffet E, Tabori U (2014) Favorable survival and metabolic outcome for children with diencephalic syndrome using a radiation-sparing approach. J Neuro Oncol 116(1):195–204. doi:10.​1007/​s11060-013-1284-2 CrossRef
115.
Hoffmann A, Gebhardt U, Sterkenburg AS, Warmuth-Metz M, Muller HL (2014) Diencephalic syndrome in childhood craniopharyngioma-results of german multicenter studies on 485 long-term survivors of childhood craniopharyngioma. J Clin Endocrinol Metab 99(11):3972–3977. doi:10.​1210/​jc.​2014-1680 PubMedCrossRef
116.
117.
Muller HL, Faldum A, Etavard-Gorris N, Gebhardt U, Oeverink R, Kolb R, Sorensen N (2003) Functional capacity, obesity and hypothalamic involvement: cross-sectional study on 212 patients with childhood craniopharyngioma. Klin Padiatr 215(6):310–314. doi:10.​1055/​s-2003-45499 PubMedCrossRef
118.
Muller HL, Bruhnken G, Emser A, Faldum A, Etavard-Gorris N, Gebhardt U, Kolb R, Sorensen N (2005) Longitudinal study on quality of life in 102 survivors of childhood craniopharyngioma. Childs Nerv Syst 21(11):975–980. doi:10.​1007/​s00381-004-1124-y PubMedCrossRef
119.
Muller HL, Gebhardt U, Faldum A, Emser A, Etavard-Gorris N, Kolb R, Sorensen N (2005) Functional capacity and body mass index in patients with sellar masses—cross-sectional study on 403 patients diagnosed during childhood and adolescence. Childs Nerv Syst 21(7):539–545. doi:10.​1007/​s00381-005-1166-9 PubMedCrossRef
120.
Muller HL, Gebhardt U, Etavard-Gorris N, Korenke E, Warmuth-Metz M, Kolb R, Sorensen N, Calaminus G (2004) Prognosis and sequela in patients with childhood craniopharyngioma—results of HIT-ENDO and update on KRANIOPHARYNGEOM 2000. Klin Padiatr 216(6):343–348. doi:10.​1055/​s-2004-832339 PubMedCrossRef
121.
Ondruch A, Maryniak A, Kropiwnicki T, Roszkowski M, Daszkiewicz P (2011) Cognitive and social functioning in children and adolescents after the removal of craniopharyngioma. Childs Nerv Syst 27(3):391–397PubMedCrossRef
122.
123.
Cavazzuti V, Fischer E, Welch K, Belli J, Winston K (1983) Neurological and psychophysiological sequelae following different treatments of craniopharyngioma in children. J Neurosurg 59(3):409–417PubMedCrossRef
124.
Riva D, Pantaleoni C, Devoti M, Saletti V, Nichelli F, Giorgi C (1998) Late neuropsychological and behavioral outcome of children surgically treated for craniopharyngioma. Childs Nerv Syst 14:179–184PubMedCrossRef
125.
Kiehna E, Mulhern R, Li C, Xiong X, Merchant T (2006) Changes in attentional performance of children and young adults iwth localized primary brain tumors after conformal radiation therapy. J Clin Oncol 24(33):5283–5290PubMedCrossRef
126.
Carpentieri S, Waber D, Scott R, Goumnerova L, Kieran M, Cohen L, Kim F, Billett A, Tarbell N, Pomeroy S (2001) Memory deficits among children with craniopharyngioma. Neurosurgery 49(5):1053–1058PubMed
127.
Sands S, Milner J, Goldberg J, Mukhi V, Moliterno J, Maxfield C, Wisoff J (2005) Quality of life and behavioral follow-up study of pediatric survivors of cranipharyngioma. J Neurosurg Pediatr 103:302–311CrossRef
128.
129.
Colangelo M, Ambrosio A, Ambrosio C (1990) Neurological and behavioral sequelae following different approaches to craniopharyngioma. Long-term follow-up review and therapeutic guidelines. Childs Nerv Syst 6(7):379–382PubMedCrossRef
130.
Metzler-Baddeley C, Jones R (2010) Brief communication: cognitive rehabilitation of executive functioning in a case of craniopharyngioma. Appl Neuropsychol 17:299–304PubMedCrossRef
131.
Hammond J, Hall S (2011) Functional analysis and treatment of aggressive behavior following resection of a craniopharyngioma. Dev Med Child Neurol 53:369–374PubMedPubMedCentralCrossRef
132.
Hetelekidis S, Barnes PD, Tao ML, Fischer EG, Schneider L, Scott RM, Tarbell NJ (1993) 20-year experience in childhood craniopharyngioma. Int J Radiat Oncol Biol Phys 27(2):189–195PubMedCrossRef
133.
Liu AK, Bagrosky B, Fenton LZ, Gaspar LE, Handler MH, McNatt SA, Foreman NK (2009) Vascular abnormalities in pediatric craniopharyngioma patients treated with radiation therapy. Pediatr Blood Cancer 52(2):227–230. doi:10.​1002/​pbc.​21787 PubMedCrossRef
134.
Regine WF, Kramer S (1992) Pediatric craniopharyngiomas: long term results of combined treatment with surgery and radiation. Int J Radiat Oncol Biol Phys 24(4):611–617PubMedCrossRef
135.
Rajan B, Ashley S, Gorman C, Jose CC, Horwich A, Bloom HJ, Marsh H, Brada M (1993) Craniopharyngioma–a long-term results following limited surgery and radiotherapy. Radiother Oncol 26(1):1–10PubMedCrossRef
136.
Stripp DC, Maity A, Janss AJ, Belasco JB, Tochner ZA, Goldwein JW, Moshang T, Rorke LB, Phillips PC, Sutton LN, Shu HK (2004) Surgery with or without radiation therapy in the management of craniopharyngiomas in children and young adults. Int J Radiat Oncol Biol Phys 58(3):714–720. doi:10.​1016/​S0360-3016(03)01570-0 PubMedCrossRef
137.
Karavitaki N, Brufani C, Warner JT, Adams CB, Richards P, Ansorge O, Shine B, Turner HE, Wass JA (2005) Craniopharyngiomas in children and adults: systematic analysis of 121 cases with long-term follow-up. Clin Endocrinol 62(4):397–409. doi:10.​1111/​j.​1365-2265.​2005.​02231.​x CrossRef
138.
139.
Moon SH, Kim IH, Park SW, Kim I, Hong S, Park CI, Wang KC, Cho BK (2005) Early adjuvant radiotherapy toward long-term survival and better quality of life for craniopharyngiomas–a study in single institute. Childs Nerv Syst 21(8–9):799–807. doi:10.​1007/​s00381-005-1189-2 PubMedCrossRef
140.
Merchant TE, Kiehna EN, Kun LE, Mulhern RK, Li C, Xiong X, Boop FA, Sanford RA (2006) Phase II trial of conformal radiation therapy for pediatric patients with craniopharyngioma and correlation of surgical factors and radiation dosimetry with change in cognitive function. J Neurosurg 104(2 Suppl):94–102. doi:10.​3171/​ped.​2006.​104.​2.​5 PubMed
141.
Nagata T, Goto T, Ichinose T, Mitsuhashi Y, Tsuyuguchi N, Ohata K (2010) Pathological findings of fusiform dilation of the internal carotid artery following radical dissection of a craniopharyngioma. J Neurosurg Pediatr 6(6):567–571. doi:10.​3171/​2010.​9.​PEDS10280 PubMedCrossRef
142.
Bendszus M, Sorensen N, Hofmann E, Roll E, Solymosi L (1998) Fusiform dilatations of the internal carotid artery following surgery for pediatric suprasellar tumors. Pediatr Neurosurg 29(6):304–308PubMedCrossRef
143.
Hoffmann A, Warmuth-Metz M, Lohle K, Reichel J, Daubenbuchel AM, Sterkenburg AS, Muller HL (2016) Fusiform dilatation of the internal carotid artery in childhood-onset craniopharyngioma: multicenter study on incidence and long-term outcome. Pituitary 19(4):422–428. doi:10.​1007/​s11102-016-0722-5 PubMedCrossRef
144.
Regine WF, Mohiuddin M, Kramer S (1993) Long-term results of pediatric and adult craniopharyngiomas treated with combined surgery and radiation. Radiother Oncol 27(1):13–21PubMedCrossRef
145.
Habrand JL, Ganry O, Couanet D, Rouxel V, Levy-Piedbois C, Pierre-Kahn A, Kalifa C (1999) The role of radiation therapy in the management of craniopharyngioma: a 25-year experience and review of the literature. Int J Radiat Oncol Biol Phys 44(2):255–263PubMedCrossRef
146.
Bulow B, Attewell R, Hagmar L, Malmstrom P, Nordstrom CH, Erfurth EM (1998) Postoperative prognosis in craniopharyngioma with respect to cardiovascular mortality, survival, and tumor recurrence. J Clin Endocrinol Metab 83(11):3897–3904PubMed
147.
Pereira AM, Schmid EM, Schutte PJ, Voormolen JH, Biermasz NR, van Thiel SW, Corssmit EP, Smit JW, Roelfsema F, Romijn JA (2005) High prevalence of long-term cardiovascular, neurological and psychosocial morbidity after treatment for craniopharyngioma. Clin Endocrinol 62(2):197–204. doi:10.​1111/​j.​1365-2265.​2004.​02196.​x CrossRef
148.
Fisher PG, Jenab J, Gopldthwaite PT, Tihan T, Wharam MD, Foer DR, Burger PC (1998) Outcomes and failure patterns in childhood craniopharyngiomas. Childs Nerv Syst 14(10):558–563PubMedCrossRef
149.
150.
Muller HL, Gebhardt U, Pohl F, Flentje M, Emser A, Warmuth-Metz M, Kolb R, Calaminus G, Sorensen N (2006) Relapse pattern after complete resection and early progression after incomplete resection of childhood craniopharyngioma. Klin Padiatr 218(6):315–320. doi:10.​1055/​s-2006-942249 PubMedCrossRef
151.
Kalapurakal JA, Goldman S, Hsieh YC, Tomita T, Marymont MH (2003) Clinical outcome in children with craniopharyngioma treated with primary surgery and radiotherapy deferred until relapse. Med Pediatr Oncol 40(4):214–218. doi:10.​1002/​mpo.​10247 PubMedCrossRef
152.
Khafaga Y, Jenkin D, Kanaan I, Hassounah M, Al Shabanah M, Gray A (1998) Craniopharyngioma in children. Int J Radiat Oncol Biol Phys 42(3):601–606PubMedCrossRef
153.
154.
Scott RM, Hetelekidis S, Barnes PD, Goumnerova L, Tarbell NJ (1994) Surgery, radiation, and combination therapy in the treatment of childhood craniopharyngioma–a 20-year experience. Pediatr Neurosurg 21(Suppl 1):75–81PubMed
155.
156.
157.
158.
159.
Petito CK, DeGirolami U, Earle KM (1976) Craniopharyngiomas: a clinical and pathological review. Cancer 37(4):1944–1952PubMedCrossRef
160.
Daubenbuchel AM, Hoffmann A, Gebhardt U, Warmuth-Metz M, Sterkenburg AS, Muller HL (2015) Hydrocephalus and hypothalamic involvement in pediatric patients with craniopharyngioma or cysts of Rathke’s pouch: impact on long-term prognosis. Eur J Endocrinol 172(5):561–569. doi:10.​1530/​EJE-14-1029 PubMedCrossRef
161.
Pickering L, Jennum P, Gammeltoft S, Poulsgaard L, Feldt-Rasmussen U, Klose M (2014) Sleep-wake and melatonin pattern in craniopharyngioma patients. Eur J Endocrinol 170(6):873–884. doi:10.​1530/​EJE-13-1025 PubMedCrossRef
162.
163.
164.
165.
166.
167.
Holmer H, Popovic V, Ekman B, Follin C, Siversson AB, Erfurth EM (2011) Hypothalamic involvement and insufficient sex steroid supplementation are associated with low bone mineral density in women with childhood onset craniopharyngioma. Eur J Endocrinol 165(1):25–31. doi:10.​1530/​EJE-11-0229 PubMedCrossRef
168.
Muller HL, Schneider P, Bueb K, Etavard-Gorris N, Gebhardt U, Kolb R, Sorensen N (2003) Volumetric bone mineral density in patients with childhood craniopharyngioma. Exp Clin Endocrinol Diabetes 111(3):168–173. doi:10.​1055/​s-2003-39789 PubMedCrossRef
169.
170.
Szeifert GT, Sipos L, Horvath M, Sarker MH, Major O, Salomvary B, Czirjak S, Balint K, Slowik F, Kolonics L et al (1993) Pathological characteristics of surgically removed craniopharyngiomas: analysis of 131 cases. Acta Neurochir 124(2–4):139–143PubMedCrossRef
171.
Metadata
Title
Risk-adapted, long-term management in childhood-onset craniopharyngioma
Author
Hermann L. Müller
Publication date
01-04-2017
Publisher
Springer US
Published in
Pituitary / Issue 2/2017
Print ISSN: 1386-341X
Electronic ISSN: 1573-7403
DOI
https://doi.org/10.1007/s11102-016-0751-0

Other articles of this Issue 2/2017

Pituitary 2/2017 Go to the issue

Letter

Patients cured of acromegaly do not experience improvement of their skull deformities

OriginalPaper

Lymphocytic hypophysitis: modern day management with limited role for surgery

OriginalPaper

Effects of somatostatin and its analogues on progenitor mesenchymal cells isolated from human pituitary adenomas

ReviewPaper

How effective is temozolomide for treating pituitary tumours and when should it be used?

OriginalPaper

Immunoprofiling of glial tumours of the neurohypophysis suggests a common pituicytic origin of neoplastic cells

OriginalPaper

Critical review of IgG4-related hypophysitis
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Reserve your place

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

Read more

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Pediatric Cardiology Video

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

Cardiopulmonary Comorbidity Video

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Valvular Heart Disease Video

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

Watch now

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits