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Child's Nervous System
Published in: Child's Nervous System 7/2005

01-07-2005 | Invited Paper

Functional capacity and body mass index in patients with sellar masses—cross-sectional study on 403 patients diagnosed during childhood and adolescence

Authors: Hermann L. Müller, Ursel Gebhardt, Andreas Faldum, Angela Emser, Nicole Etavard-Gorris, Reinhard Kolb, Niels Sörensen

Published in: Child's Nervous System | Issue 7/2005

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Abstract

Rationale

We analyzed the impact of tumour localization and histology on functional capacity (FC) and body mass index (BMI) in children with sellar masses.

Methods

FC was evaluated using the ability scale Fertigkeitenskala Münster–Heidelberg in 403 children and adolescents with sellar masses (276 craniopharyngioma, 14 germinoma, 21 optic/chiasmatic glioma, 40 hypothalamic glioma, 13 cysts of Rathke’s cleft and 39 other sellar masses). Besides tumour localization, the influence of gender, irradiation and age at diagnosis and at evaluation on FC and BMI was analyzed. General linear models with explanatory influential variables were built.

Results

In multivariate analysis, only age at diagnosis (p<0.001) and hypothalamic involvement (p=0.005) had relevant impact on FC. The second model showed BMI at diagnosis (p<0,001), hypothalamic involvement (p<0.001) and craniopharyngioma (p=0,004) to influence BMI at the latest evaluation.

Conclusion

We conclude that hypothalamic involvement and young age at diagnosis had major impact on FC and BMI and should be considered as risk factors for impaired rehabilitation.
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Metadata
Title
Functional capacity and body mass index in patients with sellar masses—cross-sectional study on 403 patients diagnosed during childhood and adolescence
Authors
Hermann L. Müller
Ursel Gebhardt
Andreas Faldum
Angela Emser
Nicole Etavard-Gorris
Reinhard Kolb
Niels Sörensen
Publication date
01-07-2005
Publisher
Springer-Verlag
Published in
Child's Nervous System / Issue 7/2005
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI
https://doi.org/10.1007/s00381-005-1166-9

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