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Clinical Reviews in Allergy & Immunology

Published in:

01-08-2020 | Rhinovirus

COVID-19 and Asthma: Reflection During the Pandemic

Authors: Shuang Liu, Yuxiang Zhi, Sun Ying

Published in: Clinical Reviews in Allergy & Immunology | Issue 1/2020

Abstract

Coronavirus disease 2019 (COVID-19) is a global pandemic infectious disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), and abnormal, overactivated innate immunity and “cytokine storms” have been proposed as potential pathological mechanisms for rapid COVID-19 progression. Theoretically, asthmatic patients should have increased susceptibility and severity for SARS-CoV-2 infection due to a deficient antiviral immune response and the tendency for exacerbation elicited by common respiratory viruses. However, existing studies have not shown an expected prevalence of asthmatic individuals among COVID-19 patients. Certain aspects of type 2 immune response, including type 2 cytokines (IL-4, IL-13, etc.) and accumulation of eosinophils, might provide potential protective effects against COVID-19. Furthermore, conventional therapeutics for asthma, including inhaled corticosteroids, allergen immunotherapy (AIT), and anti-IgE monoclonal antibody, might also reduce the risks of asthmatics suffering infection of the virus through alleviating inflammation or enhancing antiviral defense. The interactions between COVID-19 and asthma deserve further attention and clarification.

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Title: COVID-19 and Asthma: Reflection During the Pandemic
Authors: Shuang Liu
Yuxiang Zhi
Sun Ying
Publication date: 01-08-2020
Publisher: Springer US
Keywords: Rhinovirus
Bronchial Asthma
Severe Acute Respiratory Syndrome Coronavirus
SARS-CoV-2
COVID-19
Cytokines
Allergen-Specific Immunotherapy
Allergen-Specific Immunotherapy
Published in: Clinical Reviews in Allergy & Immunology / Issue 1/2020
Print ISSN: 1080-0549
Electronic ISSN: 1559-0267
DOI: https://doi.org/10.1007/s12016-020-08797-3

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Illustration of figure on mountain summit/© Orapun / Stock.adobe.com, STEP AAG HeroTeaserCollection image/© Tarek / Generated with AI / Stock.adobe.com, ACC 2024 Pediatric and Congenital Heart Disease: Year in Review/© 2024 American College of Cardiology, ACC 2024 Pulmonary Vascular Disease: Year in Review/© 2024 American College of Cardiology, ACC 2024 Valvular Heart Disease: Year in Review/© 2024 American College of Cardiology, ACC 2024 HF and Cardiomyopathies: Year in Review/© 2024 American College of Cardiology, Woman out walking/© Seventyfour / stock.adobe.com (symbolic image with model), Woman checking smartwatch /© saltdium / stock.adobe.com (symbolic image with model), Cardiac catheterization/© Damian / stock.adobe.com

Keynote webinar | Spotlight on medication adherence

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Abstract

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Other articles of this Issue 1/2020

Health Effects of Trimellitic Anhydride Occupational Exposure: Insights from Animal Models and Immunosurveillance Programs

Immunogenetics of Kawasaki disease

Eczema Herpeticum: Clinical and Pathophysiological Aspects

Timing of Cow’s Milk or Cow’s Milk Formula Introduction to the Infant Diet and Atopic Risk in Children: a Systematic Review and Meta-analysis

Influence of Cosmetic Type and Distribution Channel on the Presence of Regulated Fragrance Allergens: Study of 2044 Commercial Products

Clinical Pathway for Early Diagnosis of COVID-19: Updates from Experience to Evidence-Based Practice

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