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Published in: BMC Public Health 1/2024

Open Access 01-12-2024 | Research

Resting heart rate is associated with the prevalence of chronic kidney disease in Korean adult: the Korean National Health and Nutrition Survey

Authors: Dong-Hyuk Park, Choon Hee Chung, Dong Hoon Lee, Eun Young Lee, Justin Y. Jeon

Published in: BMC Public Health | Issue 1/2024

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Abstract

Background

Chronic kidney disease (CKD) poses a significant health challenge, yet early detection remains difficult. Resting heart rate (RHR) has been shown to be a reliable indicator of type 2 diabetes, prompting interest in its potential as an independent predictor of CKD. This study aimed to investigate the association between RHR and CKD prevalence, as well as explore potential interactions between RHR and other risk factors for CKD in a sample of 25,246 adults.

Methods

Data from the Korean National Health and Nutrition Examination Survey (2011–2014) were utilized for this study, with 19,210 participants included after screening. Logistic regression analysis was employed to examine the relationship between RHR and CKD prevalence. Stratified analyses were conducted based on known risk factors for CKD.

Results

Participants with an RHR ≥ 90 bpm exhibited a 2.07-fold [95% confidence interval (CI): 1.28–3.34] and 2.22-fold (95% CI: 1.42–3.48) higher prevalence of CKD in men and women, respectively, compared to those with an RHR < 60 bpm. The association between RHR and CKD prevalence was particularly pronounced in younger participants (40–59 years vs. ≥ 60 years), individuals with diabetes (yes vs. no), and those with a longer duration of diabetes (≥ 7 years vs. < 7 years).

Conclusion

Elevated RHR was found to be significantly associated with a higher prevalence of CKD in both men and women, independent of demographic, lifestyle, and medical factors. These findings suggest that RHR could serve as a valuable predictor for undiagnosed CKD.
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Literature
1.
go back to reference Bikbov B, Purcell CA, Levey AS, Smith M, Abdoli A, Abebe M, Adebayo OM, Afarideh M, Agarwal SK, Agudelo-Botero M. Global, regional, and national burden of chronic kidney disease, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. The Lancet. 2020;395(10225):709–33.CrossRef Bikbov B, Purcell CA, Levey AS, Smith M, Abdoli A, Abebe M, Adebayo OM, Afarideh M, Agarwal SK, Agudelo-Botero M. Global, regional, and national burden of chronic kidney disease, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. The Lancet. 2020;395(10225):709–33.CrossRef
2.
go back to reference Liyanage T, Ninomiya T, Jha V, Neal B, Patrice HM, Okpechi I, Zhao M-H, Lv J, Garg AX, Knight J, et al. Worldwide access to treatment for end-stage kidney disease: a systematic review. The Lancet. 2015;385(9981):1975–82.CrossRef Liyanage T, Ninomiya T, Jha V, Neal B, Patrice HM, Okpechi I, Zhao M-H, Lv J, Garg AX, Knight J, et al. Worldwide access to treatment for end-stage kidney disease: a systematic review. The Lancet. 2015;385(9981):1975–82.CrossRef
3.
go back to reference Chuasuwan A, Pooripussarakul S, Thakkinstian A, Ingsathit A, Pattanaprateep O. Comparisons of quality of life between patients underwent peritoneal dialysis and hemodialysis: a systematic review and meta-analysis. Health Qual Life Outcomes. 2020;18(1):191.CrossRefPubMedCentralPubMed Chuasuwan A, Pooripussarakul S, Thakkinstian A, Ingsathit A, Pattanaprateep O. Comparisons of quality of life between patients underwent peritoneal dialysis and hemodialysis: a systematic review and meta-analysis. Health Qual Life Outcomes. 2020;18(1):191.CrossRefPubMedCentralPubMed
4.
go back to reference Hödlmoser S, Winkelmayer WC, Zee J, Pecoits-Filho R, Pisoni RL, Port FK, Robinson BM, Ristl R, Krenn S, Kurnikowski A, et al. Sex differences in chronic kidney disease awareness among US adults, 1999 to 2018. PLoS ONE. 2020;15(12): e0243431.CrossRefPubMedCentralPubMed Hödlmoser S, Winkelmayer WC, Zee J, Pecoits-Filho R, Pisoni RL, Port FK, Robinson BM, Ristl R, Krenn S, Kurnikowski A, et al. Sex differences in chronic kidney disease awareness among US adults, 1999 to 2018. PLoS ONE. 2020;15(12): e0243431.CrossRefPubMedCentralPubMed
5.
go back to reference Chin HJ, Ahn JM, Na KY, Chae D-W, Lee TW, Heo NJ, Kim S. The effect of the World Kidney Day campaign on the awareness of chronic kidney disease and the status of risk factors for cardiovascular disease and renal progression. Nephrol Dial Transplant. 2010;25(2):413–9.CrossRefPubMed Chin HJ, Ahn JM, Na KY, Chae D-W, Lee TW, Heo NJ, Kim S. The effect of the World Kidney Day campaign on the awareness of chronic kidney disease and the status of risk factors for cardiovascular disease and renal progression. Nephrol Dial Transplant. 2010;25(2):413–9.CrossRefPubMed
6.
go back to reference Lee DH, de Rezende LFM, Hu FB, Jeon JY, Giovannucci EL. Resting heart rate and risk of type 2 diabetes: A prospective cohort study and meta-analysis. Diabetes Metab Res Rev. 2019;35(2):e3095.CrossRefPubMed Lee DH, de Rezende LFM, Hu FB, Jeon JY, Giovannucci EL. Resting heart rate and risk of type 2 diabetes: A prospective cohort study and meta-analysis. Diabetes Metab Res Rev. 2019;35(2):e3095.CrossRefPubMed
7.
go back to reference Aune D. ó Hartaigh B, Vatten L: Resting heart rate and the risk of type 2 diabetes: a systematic review and dose–response meta-analysis of cohort studies. Nutr Metab Cardiovasc Dis. 2015;25(6):526–34.CrossRefPubMed Aune D. ó Hartaigh B, Vatten L: Resting heart rate and the risk of type 2 diabetes: a systematic review and dose–response meta-analysis of cohort studies. Nutr Metab Cardiovasc Dis. 2015;25(6):526–34.CrossRefPubMed
8.
go back to reference Colangelo LA, Yano Y, Jacobs DR, Lloyd-Jones DM. Association of Resting Heart Rate With Blood Pressure and Incident Hypertension Over 30 Years in Black and White Adults. Hypertension. 2020;76(3):692–8.CrossRefPubMed Colangelo LA, Yano Y, Jacobs DR, Lloyd-Jones DM. Association of Resting Heart Rate With Blood Pressure and Incident Hypertension Over 30 Years in Black and White Adults. Hypertension. 2020;76(3):692–8.CrossRefPubMed
9.
go back to reference Bohm M, Schumacher H, Schmieder RE, Mann JFE, Teo K, Lonn E, Sleight P, Mancia G, Linz D, Mahfoud F, et al. Resting heart rate is associated with renal disease outcomes in patients with vascular disease: results of the ONTARGET and TRANSCEND studies. J Intern Med. 2015;278(1):38–49.CrossRefPubMed Bohm M, Schumacher H, Schmieder RE, Mann JFE, Teo K, Lonn E, Sleight P, Mancia G, Linz D, Mahfoud F, et al. Resting heart rate is associated with renal disease outcomes in patients with vascular disease: results of the ONTARGET and TRANSCEND studies. J Intern Med. 2015;278(1):38–49.CrossRefPubMed
10.
go back to reference Chang YK, Fan HC, Lim PS, Chuang SY, Hsu CC. The relationship between resting heart rate and new‐onset microalbuminuria in people with type 2 diabetes: An 8‐year follow-up study. Diabet. Med. 2021;38(5):e14436. Chang YK, Fan HC, Lim PS, Chuang SY, Hsu CC. The relationship between resting heart rate and new‐onset microalbuminuria in people with type 2 diabetes: An 8‐year follow-up study. Diabet. Med. 2021;38(5):e14436.
11.
go back to reference Kweon S, Kim Y. Jang M-j, Kim Y, Kim K, Choi S, Chun C, Khang Y-H, Oh K: Data resource profile: the Korea national health and nutrition examination survey (KNHANES). Int J Epidemiol. 2014;43(1):69–77.CrossRefPubMedCentralPubMed Kweon S, Kim Y. Jang M-j, Kim Y, Kim K, Choi S, Chun C, Khang Y-H, Oh K: Data resource profile: the Korea national health and nutrition examination survey (KNHANES). Int J Epidemiol. 2014;43(1):69–77.CrossRefPubMedCentralPubMed
12.
go back to reference Eknoyan G, Lameire N, Eckardt K, Kasiske B, Wheeler D, Levin A, Stevens P, Bilous R, Lamb E, Coresh J. KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int. 2013;3(1):5–14. Eknoyan G, Lameire N, Eckardt K, Kasiske B, Wheeler D, Levin A, Stevens P, Bilous R, Lamb E, Coresh J. KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int. 2013;3(1):5–14.
13.
go back to reference Levey AS, Coresh J, Greene T, Marsh J, Stevens LA, Kusek JW, Van Lente F. Expressing the Modification of Diet in Renal Disease Study Equation for Estimating Glomerular Filtration Rate with Standardized Serum Creatinine Values. Clin Chem. 2007;53(4):766–72.CrossRefPubMed Levey AS, Coresh J, Greene T, Marsh J, Stevens LA, Kusek JW, Van Lente F. Expressing the Modification of Diet in Renal Disease Study Equation for Estimating Glomerular Filtration Rate with Standardized Serum Creatinine Values. Clin Chem. 2007;53(4):766–72.CrossRefPubMed
14.
go back to reference Genuth SM, Palmer JP, Nathan DM. Classification and Diagnosis of Diabetes. In: Cowie CC, Casagrande SS, Menke A, et al., eds. Diabetes in America. 3rd ed. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases (US); 2018. Genuth SM, Palmer JP, Nathan DM. Classification and Diagnosis of Diabetes. In: Cowie CC, Casagrande SS, Menke A, et al., eds. Diabetes in America. 3rd ed. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases (US); 2018.
15.
go back to reference Shen Y, Cai R, Sun J, Dong X, Huang R, Tian S, Wang S. Diabetes mellitus as a risk factor for incident chronic kidney disease and end-stage renal disease in women compared with men: a systematic review and meta-analysis. Endocrine. 2017;55(1):66–76.CrossRefPubMed Shen Y, Cai R, Sun J, Dong X, Huang R, Tian S, Wang S. Diabetes mellitus as a risk factor for incident chronic kidney disease and end-stage renal disease in women compared with men: a systematic review and meta-analysis. Endocrine. 2017;55(1):66–76.CrossRefPubMed
16.
go back to reference Lee YH, Armstrong EJ, Kim G, Oh J, Kang SM, Lee BW, Ahn CW, Cha BS, Lee HC, Mantzoros CS, et al. Undiagnosed diabetes is prevalent in younger adults and associated with a higher risk cardiometabolic profile compared to diagnosed diabetes. Am Heart J. 2015;170(4):760–9 (e762).CrossRefPubMed Lee YH, Armstrong EJ, Kim G, Oh J, Kang SM, Lee BW, Ahn CW, Cha BS, Lee HC, Mantzoros CS, et al. Undiagnosed diabetes is prevalent in younger adults and associated with a higher risk cardiometabolic profile compared to diagnosed diabetes. Am Heart J. 2015;170(4):760–9 (e762).CrossRefPubMed
17.
go back to reference Yun J-S, Ahn Y-B, Song K-H, Yoo K-D, Kim H-W, Park Y-M, Ko S-H. The association between abnormal heart rate variability and new onset of chronic kidney disease in patients with type 2 diabetes: A ten-year follow-up study. Diabetes Res Clin Pract. 2015;108(1):31–7.CrossRefPubMed Yun J-S, Ahn Y-B, Song K-H, Yoo K-D, Kim H-W, Park Y-M, Ko S-H. The association between abnormal heart rate variability and new onset of chronic kidney disease in patients with type 2 diabetes: A ten-year follow-up study. Diabetes Res Clin Pract. 2015;108(1):31–7.CrossRefPubMed
18.
go back to reference Mao W, Jin X, Wang H, Ye Y, Zhang L, Gu S, Wang J, Ning G, Mu Y. The Association between Resting Heart Rate and Urinary Albumin/Creatinine Ratio in Middle-Aged and Elderly Chinese Population: A Cross-Sectional Study. J Diabetes Res. 2019;9718370. Mao W, Jin X, Wang H, Ye Y, Zhang L, Gu S, Wang J, Ning G, Mu Y. The Association between Resting Heart Rate and Urinary Albumin/Creatinine Ratio in Middle-Aged and Elderly Chinese Population: A Cross-Sectional Study. J Diabetes Res. 2019;9718370.
19.
go back to reference Beere PA, Glagov S, Zarins CK. Retarding effect of lowered heart rate on coronary atherosclerosis. Science. 1984;226(4671):180–2.ADSCrossRefPubMed Beere PA, Glagov S, Zarins CK. Retarding effect of lowered heart rate on coronary atherosclerosis. Science. 1984;226(4671):180–2.ADSCrossRefPubMed
20.
go back to reference Fox K, Komajda M, Ford I, Robertson M, Böhm M, Borer JS, Steg PG, Tavazzi L, Tendera M, Ferrari R, et al. Effect of ivabradine in patients with left-ventricular systolic dysfunction: a pooled analysis of individual patient data from the BEAUTIFUL and SHIFT trials. Eur Heart J. 2013;34(29):2263–70.CrossRefPubMed Fox K, Komajda M, Ford I, Robertson M, Böhm M, Borer JS, Steg PG, Tavazzi L, Tendera M, Ferrari R, et al. Effect of ivabradine in patients with left-ventricular systolic dysfunction: a pooled analysis of individual patient data from the BEAUTIFUL and SHIFT trials. Eur Heart J. 2013;34(29):2263–70.CrossRefPubMed
21.
go back to reference Stanko P, Baka T, Repova K, Aziriova S, Krajcirovicova K, Barta A, Janega P, Adamcova M, Paulis L, Simko F. Ivabradine ameliorates kidney fibrosis in L-NAME-induced hypertension. Front Med. 2020;7:325.CrossRef Stanko P, Baka T, Repova K, Aziriova S, Krajcirovicova K, Barta A, Janega P, Adamcova M, Paulis L, Simko F. Ivabradine ameliorates kidney fibrosis in L-NAME-induced hypertension. Front Med. 2020;7:325.CrossRef
22.
go back to reference Hwang SD, Lee JH, Jhee JH, Song JH, Kim JK, Lee SW. Impact of body mass index on survival in patients undergoing peritoneal dialysis: Analysis of data from the Insan Memorial End-Stage Renal Disease Registry of Korea (1985–2014). Kidney research and clinical practice. 2019;38(2):239.CrossRefPubMedCentralPubMed Hwang SD, Lee JH, Jhee JH, Song JH, Kim JK, Lee SW. Impact of body mass index on survival in patients undergoing peritoneal dialysis: Analysis of data from the Insan Memorial End-Stage Renal Disease Registry of Korea (1985–2014). Kidney research and clinical practice. 2019;38(2):239.CrossRefPubMedCentralPubMed
23.
go back to reference Tozawa M, Iseki K, Iseki C, Kinjo K, Ikemiya Y, Takishita S. Blood Pressure Predicts Risk of Developing End-Stage Renal Disease in Men and Women. Hypertension. 2003;41(6):1341–5.CrossRefPubMed Tozawa M, Iseki K, Iseki C, Kinjo K, Ikemiya Y, Takishita S. Blood Pressure Predicts Risk of Developing End-Stage Renal Disease in Men and Women. Hypertension. 2003;41(6):1341–5.CrossRefPubMed
24.
go back to reference Strandheim A, Halland H, Saeed S, Cramariuc D, Hetland T, Lønnebakken MT, Gerdts E. Obesity-associated metabolic changes influence resting and peak heart rate in women and men. Scandinavian Cardiovascular Journal. 2015;49(6):337–43.PubMed Strandheim A, Halland H, Saeed S, Cramariuc D, Hetland T, Lønnebakken MT, Gerdts E. Obesity-associated metabolic changes influence resting and peak heart rate in women and men. Scandinavian Cardiovascular Journal. 2015;49(6):337–43.PubMed
25.
go back to reference Park D-H, Goo SY, Hong SH, Min J-h, Byeon JY, Lee M-K, et al. Prognostic Value of Resting Heart Rate in Predicting Undiagnosed Diabetes in Adults: Korean National Health and Nutrition Examination Survey 2008–2018. Nutr Metab Cardiovasc Dis. 2023;33(1):141–50. Park D-H, Goo SY, Hong SH, Min J-h, Byeon JY, Lee M-K, et al. Prognostic Value of Resting Heart Rate in Predicting Undiagnosed Diabetes in Adults: Korean National Health and Nutrition Examination Survey 2008–2018. Nutr Metab Cardiovasc Dis. 2023;33(1):141–50.
26.
go back to reference Yang HI, Kim HC, Jeon JY. The association of resting heart rate with diabetes, hypertension, and metabolic syndrome in the Korean adult population: The fifth Korea National Health and Nutrition Examination Survey. Clin Chim Acta. 2016;455:195–200.CrossRefPubMed Yang HI, Kim HC, Jeon JY. The association of resting heart rate with diabetes, hypertension, and metabolic syndrome in the Korean adult population: The fifth Korea National Health and Nutrition Examination Survey. Clin Chim Acta. 2016;455:195–200.CrossRefPubMed
27.
go back to reference Inoue T, Iseki K, Iseki C, Ohya Y, Kinjo K, Takishita S. Heart rate as a risk factor for developing chronic kidney disease: longitudinal analysis of a screened cohort. Clin Exp Nephrol. 2009;13(5):487–93.CrossRefPubMed Inoue T, Iseki K, Iseki C, Ohya Y, Kinjo K, Takishita S. Heart rate as a risk factor for developing chronic kidney disease: longitudinal analysis of a screened cohort. Clin Exp Nephrol. 2009;13(5):487–93.CrossRefPubMed
Metadata
Title
Resting heart rate is associated with the prevalence of chronic kidney disease in Korean adult: the Korean National Health and Nutrition Survey
Authors
Dong-Hyuk Park
Choon Hee Chung
Dong Hoon Lee
Eun Young Lee
Justin Y. Jeon
Publication date
01-12-2024
Publisher
BioMed Central
Published in
BMC Public Health / Issue 1/2024
Electronic ISSN: 1471-2458
DOI
https://doi.org/10.1186/s12889-024-17877-4

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