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BMC Public Health
Published in: BMC Public Health 1/2024

Open Access 01-12-2024 | Neuroblastoma | Research

Trends in incidence and survival of childhood cancers in Khon Kaen, Thailand (2000–2019): a population-based Khon Kaen Cancer Registry study

Authors: Chanaporn Pinsuwan, Chalongpon Santong, Su-on Chainansamit, Patcharee Komvilaisak, Prapassara Sirikarn, Surachai Phimha, Kunanya Suwannaying

Published in: BMC Public Health | Issue 1/2024

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Abstract

Background

In Thailand, the national health care system and nationwide standard treatment protocols have evolved over time, potentially influencing the trends in the incidence and survival rates of childhood cancers. However, further investigations are required to comprehensively study these trends in Khon Kaen, Thailand.

Methods

Childhood cancer patients aged 0–14 years (n = 541) who were diagnosed with one of the five most common cancers between 2000 and 2019 from the population-based Khon Kaen Cancer Registry were enrolled. Descriptive statistics were used to analyse the demographic data, which are presented as numbers, percentages, means, and standard deviations. The trends in incidence between 2000 and 2019, including age-standardized incidence rates (ASRs) and annual percent changes (APCs), were analysed using the Joinpoint regression model. Survival analysis was performed for 5-year relative survival rates (RSRs) according to the Pohar Perme estimator and Kaplan–Meier survival curves.

Results

The ASRs of the overall top 5 childhood cancer groups were 67.96 and 106.12 per million person-years in 2000 and 2019, respectively. Overall, the APC significantly increased by 2.37% each year for both sexes. The overall 5-year RSRs were 60.5% for both sexes, 58.2% for males, and 63.9% for females. The highest 5-year RSR was for germ cell tumours (84.3%), whereas the lowest 5-year RSR was for neuroblastoma (29.1%).

Conclusions

The incidence and survival rates of childhood cancers in Khon Kaen, Thailand, varied according to sex. The incidence trends increased over time, meanwhile, the relative survival rates rose to satisfactory levels and were comparable to those of other nations with similar financial status. The implementation of national health policies and adherence to national treatment guidelines have improved cancer diagnosis and treatment outcomes.
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Literature
1.
2.
Bidwell SS, Peterson CC, Demanelis K, Zarins KR, Meza R, Sriplung H, et al. Childhood cancer incidence and survival in Thailand: a comprehensive population-based registry analysis, 1990–2011. Pediatr Blood Cancer. 2019;66(1):e27428.CrossRefPubMed
3.
Brand NR, Qu LG, Chao A, Ilbawi AM. Delays and barriers to cancer care in low- and middle-income countries: a systematic review. Oncologist. 2019;24(12):e1371–80.CrossRefPubMedPubMedCentral
4.
Sakunphanit T, Suwanrada W. The Universal Coverage Scheme. In: UNDP, SU/SSC, ILO, editors. Sharing Innovative Experiences: Successful Social Protection Floor Experiences. Vol. 18. New York: UNDP; 2011:385-400.
5.
Meemon N, Paek SC. Health-seeking behavior of the uninsured before and after the universal coverage scheme in Thailand. Asia Pac Soc Sci Rev. 2018;18(1):1–14.
6.
Wiangnon S, Veerakul G, Nuchprayoon I, Seksarn P, Hongeng S, Krutvecho T, et al. Childhood cancer incidence and survival 2003–2005, Thailand: study from the Thai Pediatric Oncology Group. Asian Pac J Cancer Prev. 2011;12(9):2215–20.PubMed
7.
Suwannaying K, Monsereenusorn C, Rujkijyanont P, Techavichit P, Phuakpet K, Pongphitcha P, et al. Treatment outcomes among high-risk neuroblastoma patients receiving non-immunotherapy regimen: multicenter study on behalf of the Thai Pediatric Oncology Group. Pediatr Blood Cancer. 2022;69(9):e29757.CrossRefPubMed
8.
Huang J, Chan SC, Ngai CH, Lok V, Zhang L, Lucero-Prisno DE 3rd, et al. Global incidence, mortality and temporal trends of cancer in children: a joinpoint regression analysis. Cancer Med. 2023;12(2):1903–11.CrossRefPubMed
9.
Aungkulanon S, Tangcharoensathien V, Shibuya K, Bundhamcharoen K, Chongsuvivatwong V. Post universal health coverage trend and geographical inequalities of mortality in Thailand. Int J Equity Health. 2016;15(1):190.CrossRefPubMedPubMedCentral
10.
Suwanrungruang K, Kamsa-ard S, Wiangnon S. Data quality of childhood cancer in Khon Kaen, Thailand, 1990–2007. Asian Pac J Cancer Prev. 2014;15(18):7985–7.CrossRefPubMed
11.
Walter SD, Elwood JM. A test for seasonality of events with a variable population at risk. Br J Prev Soc Med. 1975;29(1):18–21.PubMedPubMedCentral
12.
13.
StataCorp. Stata statistical software: release 15. 15th ed. College Station: StataCorp LLC; 2017.
14.
15.
Baade P, Youlden D, Valery P, Hassall T, Ward L, Green A, et al. Trends in incidence of childhood cancer in Australia, 1983–2006. Br J Cancer. 2010;102(3):620–6.CrossRefPubMedPubMedCentral
16.
Paapsi K, Baburin A, Mikkel S, Mägi M, Saks K, Innos K. Childhood cancer incidence and survival trends in Estonia (1970–2016): a nationwide population-based study. BMC Cancer. 2020;20(1):1–12.CrossRef
17.
Yiengprugsawan V, Carmichael GA, Lim LL, Seubsman SA, Sleigh AC. Has universal health insurance reduced socioeconomic inequalities in urban and rural health service use in Thailand? Health Place. 2010;16(5):1030–7.CrossRefPubMedPubMedCentral
18.
Nakata K, Ito Y, Magadi W, Bonaventure A, Stiller CA, Katanoda K, et al. Childhood cancer incidence and survival in Japan and England: a population-based study (1993–2010). Cancer Sci. 2018;109(2):422–34.CrossRefPubMed
19.
Virani S, Bilheem S, Chansaard W, Chitapanarux I, Daoprasert K, Khuanchana S, et al. National and subnational population-based incidence of cancer in Thailand: assessing cancers with the highest burdens. Cancers. 2017;9(8):108.CrossRefPubMedPubMedCentral
20.
Filippini T, Heck JE, Malagoli C, Del Giovane C, Vinceti M. A review and meta-analysis of outdoor air pollution and risk of childhood leukemia. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2015;33(1):36–66.CrossRefPubMedPubMedCentral
21.
Sakunkoo P, Thonglua T, Sangkham S, Jirapornkul C, Limmongkon Y, Daduang S, et al. Human health risk assessment of PM(2.5)-bound heavy metal of anthropogenic sources in the Khon Kaen Province of Northeast Thailand. Heliyon. 2022;8(6):e09572.CrossRefPubMedPubMedCentral
22.
Patel DM, Jones RR, Booth BJ, Olsson AC, Kromhout H, Straif K, et al. Parental occupational exposure to pesticides, animals and organic dust and risk of childhood leukemia and central nervous system tumors: findings from the International Childhood Cancer Cohort Consortium (I4C). Int J Cancer. 2020;146(4):943–52.CrossRefPubMed
23.
Karim-Kos HE, Hackl M, Mann G, Urban C, Woehrer A, Slavc I, et al. Trends in incidence, survival and mortality of childhood and adolescent cancer in Austria, 1994–2011. Cancer Epidemiol. 2016;42:72–81.CrossRefPubMed
24.
Fan Y, Zhang X, Gao C, Jiang S, Wu H, Liu Z, et al. Burden and trends of brain and central nervous system cancer from 1990 to 2019 at the global, regional, and country levels. Arch Public Health. 2022;80(1):209.CrossRefPubMedPubMedCentral
25.
Abuhamed J, Nikkilä A, Raitanen J, Alimam W, Lohi O, Pitkäniemi J, et al. Incidence trends of childhood central nervous system tumors in Finland 1990–2017. BMC Cancer. 2022;22(1):784.CrossRefPubMedPubMedCentral
26.
Tangcharoensathien V, Witthayapipopsakul W, Panichkriangkrai W, Patcharanarumol W, Mills A. Health systems development in Thailand: a solid platform for successful implementation of universal health coverage. Lancet. 2018;391(10126):1205–23.CrossRefPubMed
27.
Rojjananukulpong R, Ahmad MM, Saqib SE. Disparities in physical accessibility among rural Thais under universal health coverage. Am J Trop Med Hyg. 2021;105(3):837.CrossRefPubMedPubMedCentral
28.
Sumriddetchkajorn K, Shimazaki K, Ono T, Kusaba T, Sato K, Kobayashi N. Universal health coverage and primary care, Thailand. Bull World Health Organ. 2019;97(6):415.CrossRefPubMedPubMedCentral
29.
Schindler M, Belle FN, Grotzer MA, von der Weid NX, Kuehni CE, Group SPO. Childhood cancer survival in Switzerland (1976–2013): time-trends and predictors. Int J Cancer. 2017;140(1):62–74.CrossRefPubMed
30.
Schulpen M, Visser O, Reedijk AM, Kremer LC, Zwaan CM, Eggermont AM, et al. Significant improvement in survival of advanced stage childhood and young adolescent cancer in the Netherlands since the 1990s. Eur J Cancer. 2021;157:81–93.CrossRefPubMed
31.
Sankaranarayanan R, Ramadas K, Qiao Yl. Managing the changing burden of cancer in Asia. BMC Med. 2014;12(1):1–17.CrossRef
32.
Chalkidou K, Marquez P, Dhillon PK, Teerawattananon Y, Anothaisintawee T, Gadelha CAG, et al. Evidence-informed frameworks for cost-effective cancer care and prevention in low, middle, and high-income countries. Lancet Oncol. 2014;15(3):e119–31.CrossRefPubMed
33.
Issaragrisil S. Hematopoietic stem cell transplantation in Thailand. Bone Marrow Transplant. 2008;42 Suppl 1:S137–8.CrossRefPubMed
34.
Gupta S, Howard SC, Hunger SP, Antillon FG, Metzger ML, Israels T, et al. Treating childhood cancer in low-and middle-income countries. Cancer. 2015;3:121–46.
Metadata
Title
Trends in incidence and survival of childhood cancers in Khon Kaen, Thailand (2000–2019): a population-based Khon Kaen Cancer Registry study
Authors
Chanaporn Pinsuwan
Chalongpon Santong
Su-on Chainansamit
Patcharee Komvilaisak
Prapassara Sirikarn
Surachai Phimha
Kunanya Suwannaying
Publication date
01-12-2024
Publisher
BioMed Central
Published in
BMC Public Health / Issue 1/2024
Electronic ISSN: 1471-2458
DOI
https://doi.org/10.1186/s12889-024-18742-0

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