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BMC Pregnancy and Childbirth

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Open Access 01-12-2021 | Respiratory Microbiota | Research article

Association between premature ovarian insufficiency and gut microbiota

Authors: Jiaman Wu, Yuanyuan Zhuo, Yulei Liu, Yan Chen, Yan Ning, Jilong Yao

Published in: BMC Pregnancy and Childbirth | Issue 1/2021

Abstract

Background

Premature ovarian insufficiency (POI) is characterized by impairment of ovarian function on a continuum before the age of 40 years. POI is affected by multiple factors. Considering new insights from recent gut microbiome studies, this study aimed to investigate the relationship between gut microbial community structure and POI.

Methods

Subjects were recruited at the Shenzhen Maternity & Child Healthcare Hospital. Fecal microbial community profiles of healthy women (n = 18), women with POI (n = 35) were analyzed using 16S rRNA gene sequencing based on Illumina NovaSeq platform.

Results

Compared to the controls, the serum levels of FSH, LH, T and FSH/LH ratio significantly increased in women with POI, whereas E2 and AMH decreased significantly. Higher weighted UniFrac value was observed in POI women compared with healthy women. Phylum Firmicutes, genera Bulleidia and Faecalibacterium were more abundant in healthy women, while phylum Bacteroidetes, genera Butyricimonas, Dorea, Lachnobacterium and Sutterella enriched significantly in women with POI. Moreover, these alterations of the gut microbiome in women with POI were closely related to FSH, LH, E2, AMH level and FSH/LH ratio.

Conclusions

Women with POI had altered microbial profiles in their gut microbiome, which were associated with serum hormones levels. These results will shed a new light on the pathogenesis and treatment for POI.

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Title: Association between premature ovarian insufficiency and gut microbiota
Authors: Jiaman Wu
Yuanyuan Zhuo
Yulei Liu
Yan Chen
Yan Ning
Jilong Yao
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Respiratory Microbiota
Progesterone
Estradiol
Testosterone
Published in: BMC Pregnancy and Childbirth / Issue 1/2021
Electronic ISSN: 1471-2393
DOI: https://doi.org/10.1186/s12884-021-03855-w

2024 ASCO Annual Meeting

Springer Medicine

Association between premature ovarian insufficiency and gut microbiota

Abstract

Background

Methods

Results

Conclusions

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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