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European Journal of Clinical Microbiology & Infectious Diseases
Published in: European Journal of Clinical Microbiology & Infectious Diseases 11/2020

Open Access 01-11-2020 | Respiratory Microbiota | Review

Is Porphyromonas gingivalis involved in Parkinson’s disease?

Authors: Ingar Olsen, Douglas B. Kell, Etheresia Pretorius

Published in: European Journal of Clinical Microbiology & Infectious Diseases | Issue 11/2020

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Abstract

Porphyromonas gingivalis, a major subgingival plaque bacterium in periodontitis, has recently attracted much attention as a possible microbial driver in Alzheimer’s disease. In the present paper, another common neuroinflammatory disease, Parkinson’s disease (PD), is discussed. A recent study found major virulence factors of P. gingivalis such as gingipain R1 (RgpA) and lipopolysaccharide in the blood circulation of a PD population. The current review reveals how features such as systemic inflammation, hypercoagulation, presence of amyloid fibrin(ogen) in plasma, and marked ultrastructural changes in platelets, probably induced by P. gingivalis, may affect the development of PD. Several other clinical studies have also demonstrated an association between periodontitis and PD. Even if the risk of periodontal diseases causing neurological disorders needs to be better substantiated, that should not keep us from trying to prevent them by performing careful daily dental hygiene.
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Metadata
Title
Is Porphyromonas gingivalis involved in Parkinson’s disease?
Authors
Ingar Olsen
Douglas B. Kell
Etheresia Pretorius
Publication date
01-11-2020
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Clinical Microbiology & Infectious Diseases / Issue 11/2020
Print ISSN: 0934-9723
Electronic ISSN: 1435-4373
DOI
https://doi.org/10.1007/s10096-020-03944-2

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