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Current Oral Health Reports

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01-06-2019 | Alzheimer's Disease | Microbiology (C Genco, Section Editor)

Poor Oral Health and Its Neurological Consequences: Mechanisms of Porphyromonas gingivalis Involvement in Cognitive Dysfunction

Authors: Ingar Olsen, Sim K. Singhrao

Published in: Current Oral Health Reports | Issue 2/2019

Abstract

Purpose of Review

There is an increasing body of evidence from epidemiology and laboratory investigations demonstrating periodontal disease as a risk factor for dementia. In particular, Porphyromonas gingivalis infections in animal models suggest causal associations with Alzheimer’s disease (AD). This review focuses on how P. gingivalis infections promote the incidence of functional loss in AD.

Recent Findings

The risk of the sporadic form of AD doubles when periodontitis persists for ten or more years. AD differs from other forms of dementia in that the clinical signs together with the presence of amyloid-beta (Aβ) plaques and neurofibrillary tangles must be present at autopsy. P. gingivalis oral infections in mice have demonstrated all of the characteristic pathological and clinical features of AD following infection of the brain.

Summary

Multiple factors (inflammation, Aβ oligomers, and bacterial factors) are likely to disrupt neuronal communication channels (synapses) as a plausible explanation for the functional loss.

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Title: Poor Oral Health and Its Neurological Consequences: Mechanisms of Porphyromonas gingivalis Involvement in Cognitive Dysfunction
Authors: Ingar Olsen
Sim K. Singhrao
Publication date: 01-06-2019
Publisher: Springer International Publishing
Keywords: Alzheimer's Disease
Dementia
Alzheimer's Disease
Dementia
Published in: Current Oral Health Reports / Issue 2/2019
Electronic ISSN: 2196-3002
DOI: https://doi.org/10.1007/s40496-019-0212-8

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Poor Oral Health and Its Neurological Consequences: Mechanisms of Porphyromonas gingivalis Involvement in Cognitive Dysfunction

Abstract

Purpose of Review

Recent Findings

Summary

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose of Review

Recent Findings

Summary

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Vitamin Status and Mineralized Tissue Formation

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Computational Analysis of Interactions of the Oral Microbiota