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BMC Complementary Medicine and Therapies

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Open Access 01-12-2023 | Respiratory Microbiota | Research

Penthorum chinense Pursh improves type 2 diabetes mellitus via modulating gut microbiota in db/db mice

Authors: Jilei Hu, Huibo Xie, Ning Lin, Yan Yang

Published in: BMC Complementary Medicine and Therapies | Issue 1/2023

Abstract

Penthorum chinense Pursh (P. chinense) has been traditionally used as hepatoprotective food and medicine for hundreds of years due to its significant antioxidant and anti-inflammatory activities. However, the efficacy and mechanisms of action of P. chinense in type 2 diabetes mellitus were not fully understood. In this study, we found that P. chinense extract (PCP) supplementation resulted in reduced body weight and hyperglycemia, improved pancreatic tissue injury and insulin sensitivity, and decreased inflammatory cytokines expression in spontaneously diabetic db/db mice. 16S rRNA gene sequencing of fecal samples showed that PCP administration decreased the abundance of Firmicutes and increased the proportion of Bacteroidetes at the phylum level. Moreover, Muribaculum, Barnesiella, Prevotella, and Mucinivorans were enriched, with Desulfovibrio and Lactobacillus lowered at the genus level in db/db mice with PCP supplementation. These results suggested that PCP may ameliorate hyperglycemia, insulin resistance, and inflammation by remodeling the gut microbiota in db/db mice.

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Title: Penthorum chinense Pursh improves type 2 diabetes mellitus via modulating gut microbiota in db/db mice
Authors: Jilei Hu
Huibo Xie
Ning Lin
Yan Yang
Publication date: 01-12-2023
Publisher: BioMed Central
Keywords: Respiratory Microbiota
Insulins
Insulins
Diabetes
Published in: BMC Complementary Medicine and Therapies / Issue 1/2023
Electronic ISSN: 2662-7671
DOI: https://doi.org/10.1186/s12906-023-04136-z

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Penthorum chinense Pursh improves type 2 diabetes mellitus via modulating gut microbiota in db/db mice

Abstract

Keynote webinar | Spotlight on medication adherence

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