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European Journal of Nutrition
Published in: European Journal of Nutrition 5/2021

01-08-2021 | Respiratory Microbiota | Original Contribution

Blueberry and cranberry anthocyanin extracts reduce bodyweight and modulate gut microbiota in C57BL/6 J mice fed with a high-fat diet

Authors: Jianhui Liu, Wangjun Hao, Zouyan He, Erika Kwek, Hanyue Zhu, Ning Ma, Ka Ying Ma, Zhen-Yu Chen

Published in: European Journal of Nutrition | Issue 5/2021

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Abstract

Purpose

Blueberry and cranberry are rich in anthocyanins. The present study was to investigate the effects of anthocyanin extracts from blueberry and cranberry on body weight and gut microbiota.

Methods

C57BL/6 J Mice were divided into six groups (n = 9 each) fed one of six diets namely low-fat diet (LFD), high-fat diet (HFD), HFD with the addition of 1% blueberry extract (BL), 2% blueberry extract (BH), 1% cranberry extract (CL), and 2% cranberry extract (CH), respectively.

Results

Feeding BL and BH diets significantly decreased body weight gain by 20–23%, total adipose tissue weight by 18–20%, and total liver lipids by 16–18% compared with feeding HFD. Feeding CH diet but not CL diet reduced the body weight by 27%, accompanied by a significant reduction of total plasma cholesterol by 25% and tumor necrosis factor alpha (TNF-α) by 38%. The metagenomic analysis showed that the supplementation of blueberry and cranberry anthocyanin extracts reduced plasma lipopolysaccharide concentration, accompanied by a reduction in the relative abundance of Rikenella and Rikenellaceae. Dietary supplementation of berry anthocyanin extracts promoted the growth of Lachnoclostridium, Roseburia, and Clostridium_innocuum_group in genus level, leading to a greater production of fecal short-chain fatty acids (SCFA).

Conclusions

It was concluded that both berry anthocyanins could manage the body weight and favorably modulate the gut microbiota at least in mice.
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Metadata
Title
Blueberry and cranberry anthocyanin extracts reduce bodyweight and modulate gut microbiota in C57BL/6 J mice fed with a high-fat diet
Authors
Jianhui Liu
Wangjun Hao
Zouyan He
Erika Kwek
Hanyue Zhu
Ning Ma
Ka Ying Ma
Zhen-Yu Chen
Publication date
01-08-2021
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Nutrition / Issue 5/2021
Print ISSN: 1436-6207
Electronic ISSN: 1436-6215
DOI
https://doi.org/10.1007/s00394-020-02446-3

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