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International Orthopaedics
Published in: International Orthopaedics 11/2011

01-11-2011 | Letter to the Editor

Reply to comments of Carmona et al. to the article: Regenerative medicine for the treatment of musculoskeletal overuse injuries in competition horses

Authors: Paola Torricelli, Giuseppe Filardo, Elizaveta Kon, Milena Fini

Published in: International Orthopaedics | Issue 11/2011

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Excerpt

In a recently published study, we documented our experience using platelet-rich plasma (PRP) and concentrated bone marrow mononucleated cells (BMMNCs) for the treatment of musculoskeletal injuries (ligament and tendon overuse injuries) in competition horses refractory to other therapies [1]. We evaluated number of cells and presence of growth factors (GFs) injected, and performed follow-ups on horses weekly, up to one year. The results of our study showed a marked improvement in the degree of lameness, with 84.6% of horses returning to competition, and a direct correlation between number of platelets injected and clinical outcome. …
Literature
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Torricelli P, Fini M, Filardo G et al (2011) Regenerative medicine for the treatment of musculoskeletal overuse injuries in competition horses. Int Orthop. doi:10.​1007/​s00264-011-1237-3
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Kon E, Filardo G, Delcogliano M et al (2010) Platelet autologous growth factors decrease the osteochondral regeneration capability of a collagen-hydroxyapatite scaffold in a sheep model. BMC Musculoskelet Disord 11:220CrossRef
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Weibrich G, Hansen T, Kleis W, Buch R, Hitzler WE (2004) Effect of platelet concentration in platelet-rich plasma on peri-implant bone regeneration. Bone 34:665–671PubMedCrossRef
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Tschon M, Fini M, Giardino R et al (2011) Lights and shadows concerning platelet products for musculoskeletal regeneration. Front Biosci (Elite Ed) 3:96–107CrossRef
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Smith RKW, Korda M, Blunn GW et al (2003) Isolation and implantation of autologous equine mesenchymal stem cells from bone marrow into the superficial digital flexor tendon as a potential novel treatment. Equine Vet 35:99–102CrossRef
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Metadata
Title
Reply to comments of Carmona et al. to the article: Regenerative medicine for the treatment of musculoskeletal overuse injuries in competition horses
Authors
Paola Torricelli
Giuseppe Filardo
Elizaveta Kon
Milena Fini
Publication date
01-11-2011
Publisher
Springer-Verlag
Published in
International Orthopaedics / Issue 11/2011
Print ISSN: 0341-2695
Electronic ISSN: 1432-5195
DOI
https://doi.org/10.1007/s00264-011-1312-9

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