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Published in:

01-11-2011 | Original Paper

Intra-articular injection of tranexamic acid reduces not only blood loss but also knee joint swelling after total knee arthroplasty

Authors: Kazunari Ishida, Nobuhiro Tsumura, Atsushi Kitagawa, Sayaka Hamamura, Koji Fukuda, Yoshihiro Dogaki, Seiji Kubo, Tomoyuki Matsumoto, Takehiko Matsushita, Takaaki Chin, Tetsuhiro Iguchi, Masahiro Kurosaka, Ryosuke Kuroda

Published in: International Orthopaedics | Issue 11/2011

Abstract

Purpose

This is a randomised controlled trial to examine whether intra-articular injection of tranexamic acid (TXA) decreases blood loss, as well as reducing leg swelling after total knee arthroplasty (TKA).

Methods

We performed 100 TKA in osteoarthritis patients. At closure, a total of 2,000 mg/20 ml TXA was injected into the knee joint through a closed suction drain (TXA group). For the control group, the same volume of physiological saline was injected. The pre-operative condition of the patients, post-operative haemoglobin (Hb) levels, discharge volumes from drain, D-dimer and needs for transfusion were compared between these two groups. Furthermore, leg diameters (thigh, suprapatellar portion and calf girth) were measured pre- and post-operatively to investigate whether TXA has an influence on leg swelling after surgery.

Results

The results revealed that post-operative decrease in Hb level was significantly reduced in the TXA group. Furthermore, knee joint swelling after operation was significantly suppressed in the TXA group compared to the control group.

Conclusions

The results revealed intra-articular administration of TXA decreased not only blood loss, but also knee joint swelling after TKA.

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Title: Intra-articular injection of tranexamic acid reduces not only blood loss but also knee joint swelling after total knee arthroplasty
Authors: Kazunari Ishida
Nobuhiro Tsumura
Atsushi Kitagawa
Sayaka Hamamura
Koji Fukuda
Yoshihiro Dogaki
Seiji Kubo
Tomoyuki Matsumoto
Takehiko Matsushita
Takaaki Chin
Tetsuhiro Iguchi
Masahiro Kurosaka
Ryosuke Kuroda
Publication date: 01-11-2011
Publisher: Springer-Verlag
Published in: International Orthopaedics / Issue 11/2011
Print ISSN: 0341-2695
Electronic ISSN: 1432-5195
DOI: https://doi.org/10.1007/s00264-010-1205-3

At a glance: The STEP trials

Springer Medicine

Intra-articular injection of tranexamic acid reduces not only blood loss but also knee joint swelling after total knee arthroplasty

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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Erratum to: Relationship of serum IL-6, C-reactive protein, erythrocyte sedimentation rate, and knee skin temperature after total knee arthroplasty: a prospective study