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Journal of Clinical Immunology
Published in: Journal of Clinical Immunology 1/2016

Open Access 01-05-2016

Regulation of Monoclonal Antibody Immunotherapy by FcγRIIB

Authors: Richard J. Stopforth, Kirstie L. S. Cleary, Mark S. Cragg

Published in: Journal of Clinical Immunology | Special Issue 1/2016

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Abstract

Monoclonal antibodies (mAb) are revolutionising the treatment of many different diseases. Given their differing mode of action compared to most conventional chemotherapeutics and small molecule inhibitors, they possess the potential to be independent of common modes of treatment resistance and can typically be combined readily with existing treatments without dose-limiting toxicity. However, treatments with mAb rarely result in cure and so a full understanding of how these reagents work and can be optimised is key for their subsequent improvement. Here we review how an understanding of the biology of the inhibitory Fc receptor, FcγRIIB (CD32B), is leading to the development of improved mAb treatments.
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Metadata
Title
Regulation of Monoclonal Antibody Immunotherapy by FcγRIIB
Authors
Richard J. Stopforth
Kirstie L. S. Cleary
Mark S. Cragg
Publication date
01-05-2016
Publisher
Springer US
Published in
Journal of Clinical Immunology / Issue Special Issue 1/2016
Print ISSN: 0271-9142
Electronic ISSN: 1573-2592
DOI
https://doi.org/10.1007/s10875-016-0247-8

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