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01-02-2012 | Review Article

Regulation and dysregulation of epithelial Na⁺ channels

Authors: Lawrence G. Palmer, Ankit Patel, Gustavo Frindt

Published in: Clinical and Experimental Nephrology | Issue 1/2012

Abstract

Epithelial Na⁺ channels (ENaC) form a highly regulated pathway for the reabsorption of Na⁺ from urine. This regulation can take place at a number of different levels, including synthesis of channel protein, trafficking of the protein between the surface and internal membranes, proteolytic cleavage and channel gating. This article reviews the role of these different modes of regulation under physiological conditions and considers the possible contributions of dysregulation of these processes in disease states, particularly hypertension.

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Title: Regulation and dysregulation of epithelial Na+ channels
Authors: Lawrence G. Palmer
Ankit Patel
Gustavo Frindt
Publication date: 01-02-2012
Publisher: Springer Japan
Published in: Clinical and Experimental Nephrology / Issue 1/2012
Print ISSN: 1342-1751
Electronic ISSN: 1437-7799
DOI: https://doi.org/10.1007/s10157-011-0496-z

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