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01-05-2017 | Original Article

Regional cerebellar volumetric correlates of manual motor and cognitive function

Authors: Vincent Koppelmans, Yoo Young Hoogendam, Sarah Hirsiger, Susan Mérillat, Lutz Jäncke, Rachael D. Seidler

Published in: Brain Structure and Function | Issue 4/2017

Abstract

Cerebellar volume declines with aging. Few studies have investigated age differences in regional cerebellar volume (RCV) and their association with motor and cognitive function. In 213 healthy older adults, we investigated the association of age with motor skills, cognition and RCV. Subsequently, we studied the association of RCV with motor skills and cognition. RCVs were derived from T1-weighted MRI scans using the automated SUIT segmentation method and clustered using principal component analysis (PCA). Motor skill (manual dexterity, tapping speed, bimanual visuomotor coordination, grip force) and cognition (mental rotation, verbal memory, inhibition, mental flexibility) were assessed. Behavioral measures were clustered into compounds using PCA: left hand motor skill, right hand motor skill, verbal memory and mental flexibility, and mental rotation & inhibition. Volume of the rostral middle frontal gyri (rMFG) and premotor areas (PMA) were related to performance for reference. Analyses were adjusted for age, sex, and education. Volume of the cerebellar anterior lobe and top of the superior posterior lobe were positively associated with motor skill. Volume of the bottom part of the posterior superior lobe and the inferior posterior lobe was positively associated with cognition. PMA volume was associated with cognition and motor skill and rMFG volume with motor skill. Although these results did not survive FDR correction, their effect sizes suggest that regional cerebellar volume selectively contributes to cognitive and motor skill. Effect sizes of cerebellar associations with performance were similar to those of rMFG/PMA and performance suggesting parallel contributions to performance.

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Title: Regional cerebellar volumetric correlates of manual motor and cognitive function
Authors: Vincent Koppelmans
Yoo Young Hoogendam
Sarah Hirsiger
Susan Mérillat
Lutz Jäncke
Rachael D. Seidler
Publication date: 01-05-2017
Publisher: Springer Berlin Heidelberg
Published in: Brain Structure and Function / Issue 4/2017
Print ISSN: 1863-2653
Electronic ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-016-1317-7

At a glance: The STEP trials

Springer Medicine

Regional cerebellar volumetric correlates of manual motor and cognitive function

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At a glance: The STEP trials

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Abstract

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