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Respiratory Research
Published in: Respiratory Research 1/2006

Open Access 01-12-2006 | Research

Reference values for exhaled nitric oxide (reveno) study

Authors: Mario Olivieri, Giorgio Talamini, Massimo Corradi, Luigi Perbellini, Antonio Mutti, Claudio Tantucci, Mario Malerba

Published in: Respiratory Research | Issue 1/2006

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Abstract

Background

Despite the widespread use of fractional exhaled nitric oxide (FENO) as a biomarker of airways inflammation, there are no published papers describing normal FENO values in a large group of healthy adults.

Objective

The aim of this study was to establish adult FENO reference values according to the international guidelines.

Methods

FENO was measured in 204 healthy, non-smoking adults with normal spirometry values using the on-line single-breath technique, and the results were analysed chemiluminescently.

Results

The main result of the study was the significant difference in FENO values between men and women, thus indicating that gender-based reference FENO values are necessary. The FENO levels obtained at expiratory flows of 50 ml/s ranged from 2.6 to 28.8 ppb in men, and from 1.6 to 21.5 ppb in women.

Conclusion

We propose reference FENO values for healthy adult men and women that could be used for clinical and research purposes.
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Metadata
Title
Reference values for exhaled nitric oxide (reveno) study
Authors
Mario Olivieri
Giorgio Talamini
Massimo Corradi
Luigi Perbellini
Antonio Mutti
Claudio Tantucci
Mario Malerba
Publication date
01-12-2006
Publisher
BioMed Central
Published in
Respiratory Research / Issue 1/2006
Electronic ISSN: 1465-993X
DOI
https://doi.org/10.1186/1465-9921-7-94

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