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Respiratory Research
Published in: Respiratory Research 1/2006

Open Access 01-12-2006 | Research

Asthma families show transmission disequilibrium of gene variants in the vitamin D metabolism and signalling pathway

Authors: Matthias Wjst, Janine Altmüller, Theresia Faus-Kessler, Christine Braig, Margret Bahnweg, Elisabeth André

Published in: Respiratory Research | Issue 1/2006

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Abstract

The vitamin D prophylaxis of rickets in pregnant women and newborns may play a role in early allergic sensitization. We now asked if an already diseased population may have inherited genetic variants in the vitamin D turnover or signalling pathway.
Serum levels of calcidiol (25-OH-D3) and calcitriol (1,25-(OH)2-D3) were retrospectively assessed in 872 partipants of the German Asthma Family Study. 96 DNA single base variants in 13 different genes were genotyped with MALDI-TOF and a bead array system. At least one positive SNP with a TDT of p < 0.05 for asthma or total IgE and calcidiol or calcitriol was seen in IL10, GC, IL12B, CYP2R1, IL4R, and CYP24A1. Consistent strong genotypic association could not be observed. Haplotype association were found only for CYP24A1, the main calcidiol degrading enzyme, where a frequent 5-point-haplotype was associated with asthma (p = 0,00063), total IgE (p = 0,0014), calcidiol (p = 0,0043) and calcitriol (p = 0,0046).
Genetic analysis of biological pathways seem to be a promising approach where this may be a first entry point into effects of a polygenic inherited vitamin D sensitivity that may affect also other metabolic, immunological and cancerous diseases.
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Metadata
Title
Asthma families show transmission disequilibrium of gene variants in the vitamin D metabolism and signalling pathway
Authors
Matthias Wjst
Janine Altmüller
Theresia Faus-Kessler
Christine Braig
Margret Bahnweg
Elisabeth André
Publication date
01-12-2006
Publisher
BioMed Central
Published in
Respiratory Research / Issue 1/2006
Electronic ISSN: 1465-993X
DOI
https://doi.org/10.1186/1465-9921-7-60

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