Published in:
01-12-2013 | Original Article
Reference ranges for serum cystatin C measurements in Japanese children by using 4 automated assays
Published in: Clinical and Experimental Nephrology | Issue 6/2013
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Objective
The data available on reference ranges for cystatin C in children are limited, and there are discrepancies among the available data. The aim of this study was to describe the reference ranges for cystatin C in Japanese children by using 4 automated assays.
Methods
Serum cystatin C levels were measured in 1128 Japanese children aged 3 month to 16 years without kidney disease. We calculated age-, gender-, race- and assay-specific cystatin C ranges.
Results
For all 4 assays, the median serum cystatin C levels were raised in term infants compared with older children and decreased by the first 2 years. The median serum cystatin C levels remained constant throughout up to the age of 14 years and decreased in children aged 15–16 years. The median serum cystatin C levels in children aged 12–16 years were slightly higher in males than in females. Assay-specific differences were also observed in the levels of serum cystatin C measured.
Conclusion
Age-, gender-, race- and assay-specific ranges for serum cystatin C should be used as another tool to assess kidney function in children.