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Published in:

01-10-2010 | Original Article

Reference serum cystatin C levels in Japanese children

Authors: Osamu Uemura, Katsumi Ushijima, Takuhito Nagai, Takuji Yamada, Hideki Hayakawa, Yayoi Nabeta, Yoshiko Shinkai, Kouichi Koike, Masaki Kuwabara

Published in: Clinical and Experimental Nephrology | Issue 5/2010

Abstract

Background

Single measurements of serum cystatin C (cysC) concentration have generally been used to determine glomerular filtration rate (GFR) in adults. Since GFR varies to some extent among children, we attempted to determine reference serum cysC concentrations for Japanese children.

Methods

Serum cysC concentrations were determined by a latex particle-enhanced turbidimetric immunoassay in children who did not present with kidney disease or infectious disease, and the relationship between age and serum cysC level was assessed.

Results

We found that reference serum cysC levels gradually decreased during the first year after birth, thereafter becoming constant. Mean serum cysC concentration in children aged 1 year (0.76 ± 0.10 mg/L) was slightly higher than in children aged ≥2 years (0.70 ± 0.09 mg/L).

Conclusion

Our reference values will be applicable for screening renal function in Japanese children.

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Title: Reference serum cystatin C levels in Japanese children
Authors: Osamu Uemura
Katsumi Ushijima
Takuhito Nagai
Takuji Yamada
Hideki Hayakawa
Yayoi Nabeta
Yoshiko Shinkai
Kouichi Koike
Masaki Kuwabara
Publication date: 01-10-2010
Publisher: Springer Japan
Published in: Clinical and Experimental Nephrology / Issue 5/2010
Print ISSN: 1342-1751
Electronic ISSN: 1437-7799
DOI: https://doi.org/10.1007/s10157-010-0314-z

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