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Perioperative Medicine

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Open Access 01-12-2023 | Rectal Extirpation | Research

Safety profile of a multimodal fail-safe model to minimize postoperative complications in oncologic colorectal resections—a cohort study

Authors: Shahram Khadem, Jonas Herzberg, Human Honarpisheh, Robert Maximilian Jenner, Salman Yousuf Guraya, Tim Strate

Published in: Perioperative Medicine | Issue 1/2023

Abstract

Background

Despite innovations in surgical techniques, major complications following colorectal surgery still lead to a significant morbidity and mortality. There is no standard protocol for perioperative management of patients with colorectal cancer. This study evaluates the effectiveness of a multimodal fail-safe model in minimizing severe surgical complications following colorectal resections.

Methods

We compared major complications in patients with colorectal cancers who underwent surgical resections with anastomosis during 2013–2014 (control group) with patients treated during 2015–2019 (fail-safe group). The fail-safe group had preoperative bowel preparation and a perioperative single dose of antibiotics, on-table bowel irrigation and early sigmoidoscopic assessment of anastomosis in rectal resections. A standard surgical technique for tension-free anastomosis was adapted in the fail-safe approach. The chi-square test measured relationships between categorical variables, t-test estimated the probability of differences, and the multivariate regression analysis determined the linear correlation among independent and dependent variables.

Results

A total of 924 patients underwent colorectal operations during the study period; however, 696 patients had surgical resections with primary anastomoses. There were 427 (61.4%) laparoscopic and 230 (33.0%) open operations, while 39 (5.6%) laparoscopic procedures were converted. Overall, the rate of major complications (Dindo-Clavien grade IIIb–V) significantly reduced from 22.6% for the control group to 9.8% for the fail-safe group (p < 0.0001). Major complications mainly occurred due to non-surgical reasons such as pneumonia, heart failure, or renal dysfunction. The rates of anastomotic leakage (AL) were 11.8% (22/186) and 3.7% (n = 19/510) for the control and fail-safe groups, respectively (p < 0.0001).

Conclusion

We report an effective multimodal fail-safe protocol for colorectal cancer during the pre-, peri-, and postoperative period. The fail-safe model showed less postoperative complications even for low rectal anastomosis. This approach can be adapted as a structured protocol during the perioperative care of patients for colorectal surgery.

Trial registration

This study was registered in the German Clinical Trial Register (Study ID: DRKS00023804).

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Title: Safety profile of a multimodal fail-safe model to minimize postoperative complications in oncologic colorectal resections—a cohort study
Authors: Shahram Khadem
Jonas Herzberg
Human Honarpisheh
Robert Maximilian Jenner
Salman Yousuf Guraya
Tim Strate
Publication date: 01-12-2023
Publisher: BioMed Central
Keywords: Rectal Extirpation
Rectal Extirpation
Colorectal Cancer
Colorectal Cancer
Published in: Perioperative Medicine / Issue 1/2023
Electronic ISSN: 2047-0525
DOI: https://doi.org/10.1186/s13741-023-00291-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Safety profile of a multimodal fail-safe model to minimize postoperative complications in oncologic colorectal resections—a cohort study

Abstract

Background

Methods

Results

Conclusion

Trial registration

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

Trial registration

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