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Medical Oncology
Published in: Medical Oncology 6/2024

01-06-2024 | Rectal Cancer | Letter to the Editor

The role of radiation therapy in locally advanced rectal cancer [In regard to primary surgery followed by selective chemoradiotherapy versus preoperative chemoradiotherapy followed by surgery for locally advanced rectal cancer: a randomized clinical trial]

Author: Francesca De Felice

Published in: Medical Oncology | Issue 6/2024

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Excerpt

I read with interest the randomized clinical trial by Li et al. [1] that emphasized the importance of radiation therapy (RT) in locally advanced rectal cancer (LARC) management. During the past 30 years, major advances have helped to substantially improve the prognosis of LARC patients: (i) the use of preoperative chemoRT increased locoregional control; (ii) the advent of intensity modulated RT technique allowed a better dose distribution, assuring a better adjacent normal tissues sparing; (iii) the use of magnetic resonance imaging (MRI) assured a superior definition of local extension, especially into mesorectal fat. Consequently, the vast majority of LARC patients have a good outcome with a minimization of RT side effects. …
Literature
1.
Li J, Hu YT, Liu CC, Wang LH, Ju HX, Huang XF, Chi P, Du JL, Wang JP, Xiao Y, Lin GL, Zhang W, Zhao H, Liu M, Song YM, Xu D, Wang JW, Sun LF, Xie HT, Cao HF, Xiao Q, Wang J, Wu QB, Li DC, Dai S, Jiang WZ, Shen L, Yuan Y, Wang ZQ, Ding KF. Primary surgery followed by selective chemoradiotherapy versus preoperative chemoradiotherapy followed by surgery for locally advanced rectal cancer: A Randomized Clinical Trial. Int J Radiat Oncol Biol Phys. 2024:S0360-3016(23)08261-5.
Metadata
Title
The role of radiation therapy in locally advanced rectal cancer [In regard to primary surgery followed by selective chemoradiotherapy versus preoperative chemoradiotherapy followed by surgery for locally advanced rectal cancer: a randomized clinical trial]
Author
Francesca De Felice
Publication date
01-06-2024
Publisher
Springer US
Published in
Medical Oncology / Issue 6/2024
Print ISSN: 1357-0560
Electronic ISSN: 1559-131X
DOI
https://doi.org/10.1007/s12032-024-02371-z

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