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Seminars in Immunopathology
Published in: Seminars in Immunopathology 4/2008

01-12-2008 | Review

Reconstitution of the immune system after hematopoietic stem cell transplantation in humans

Authors: Jan Storek, Michelle Geddes, Faisal Khan, Bertrand Huard, Claudine Helg, Yves Chalandon, Jakob Passweg, Eddy Roosnek

Published in: Seminars in Immunopathology | Issue 4/2008

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Abstract

Hematopoietic stem cell transplantation is associated with a severe immune deficiency. As a result, the patient is at high risk of infections. Innate immunity, including epithelial barriers, monocytes, granulocytes, and NK cells recovers within weeks after transplantation. By contrast, adaptive immunity recovers much slower. B- and T-cell counts normalize during the first months after transplantation, but in particular, T-cell immunity may remain impaired for years. During the last decade, much of the underlying mechanisms have been identified. These insights may provide new therapies to accelerate recovery.
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Metadata
Title
Reconstitution of the immune system after hematopoietic stem cell transplantation in humans
Authors
Jan Storek
Michelle Geddes
Faisal Khan
Bertrand Huard
Claudine Helg
Yves Chalandon
Jakob Passweg
Eddy Roosnek
Publication date
01-12-2008
Publisher
Springer-Verlag
Published in
Seminars in Immunopathology / Issue 4/2008
Print ISSN: 1863-2297
Electronic ISSN: 1863-2300
DOI
https://doi.org/10.1007/s00281-008-0132-5

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