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01-12-2008 | Review

Human intrathymic development: a selective approach

Authors: J. Plum, M. De Smedt, G. Leclercq, T. Taghon, T. Kerre, B. Vandekerckhove

Published in: Seminars in Immunopathology | Issue 4/2008

Abstract

Human T lymphocytes can be generated from CD34 progenitor cells from different sources. This can be obtained in an in vivo model wherein human thymic tissue and fetal liver is transplanted in an immunodeficient mouse. However, human T cells are also generated in immunodeficient mice without co-transplantation of human thymus or in in vitro hybrid human–mouse fetal thymus organ culture. This shows that xenogeneic mouse thymus tissue supports human T cell differentiation. Finally, human T cells are generated on co-culture with murine stromal cells that express the Delta-like1 ligand for the Notch receptor. How these different environments influence the human T cell repertoire is reviewed and discussed.

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Title: Human intrathymic development: a selective approach
Authors: J. Plum
M. De Smedt
G. Leclercq
T. Taghon
T. Kerre
B. Vandekerckhove
Publication date: 01-12-2008
Publisher: Springer-Verlag
Published in: Seminars in Immunopathology / Issue 4/2008
Print ISSN: 1863-2297
Electronic ISSN: 1863-2300
DOI: https://doi.org/10.1007/s00281-008-0135-2

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