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Keynote webinar | Spotlight on medication adherence

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Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
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AIDS and Behavior
Published in: AIDS and Behavior 6/2010

Open Access 01-12-2010 | Original Paper

Real-Time Adherence Monitoring for HIV Antiretroviral Therapy

Authors: Jessica E. Haberer, Josh Kahane, Isaac Kigozi, Nneka Emenyonu, Peter Hunt, Jeffrey Martin, David R. Bangsberg

Published in: AIDS and Behavior | Issue 6/2010

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Abstract

Current adherence assessments typically detect missed doses long after they occur. Real-time, wireless monitoring strategies for antiretroviral therapy may provide novel opportunities to proactively prevent virologic rebound and treatment failure. Wisepill, a wireless pill container that transmits a cellular signal when opened, was pilot tested in ten Ugandan individuals for 6 months. Adherence levels measured by Wisepill, unannounced pill counts, and self-report were compared with each other, prior standard electronic monitoring, and HIV RNA. Wisepill data was initially limited by battery life and signal transmission interruptions. Following device improvements, continuous data was achieved with median (interquartile range) adherence levels of 93% (87–97%) by Wisepill, 100% (99–100%) by unannounced pill count, 100% (100–100%) by self-report, and 92% (79–98%) by prior standard electronic monitoring. Four individuals developed transient, low-level viremia. After overcoming technical challenges, real-time adherence monitoring is feasible for resource-limited settings and may detect suboptimal adherence prior to viral rebound.
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Metadata
Title
Real-Time Adherence Monitoring for HIV Antiretroviral Therapy
Authors
Jessica E. Haberer
Josh Kahane
Isaac Kigozi
Nneka Emenyonu
Peter Hunt
Jeffrey Martin
David R. Bangsberg
Publication date
01-12-2010
Publisher
Springer US
Published in
AIDS and Behavior / Issue 6/2010
Print ISSN: 1090-7165
Electronic ISSN: 1573-3254
DOI
https://doi.org/10.1007/s10461-010-9799-4

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Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

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WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

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