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Open Access 01-06-2009 | Original Paper

Longitudinal Antiretroviral Adherence in HIV+ Ugandan Parents and Their Children Initiating HAART in the MTCT-Plus Family Treatment Model: Role of Depression in Declining Adherence Over Time

Authors: Jayne Byakika-Tusiime, Johanna Crane, Jessica H. Oyugi, Kathleen Ragland, Annet Kawuma, Philippa Musoke, David R. Bangsberg

Published in: AIDS and Behavior | Special Issue 1/2009

Abstract

We conducted a study to assess the effect of family-based treatment on adherence amongst HIV-infected parents and their HIV-infected children attending the Mother-To-Child-Transmission Plus program in Kampala, Uganda. Adherence was assessed using home-based pill counts and self-report. Mean adherence was over 94%. Depression was associated with incomplete adherence on multivariable analysis. Adherence declined over time. Qualitative interviews revealed lack of transportation money, stigma, clinical response to therapy, drug packaging, and cost of therapy may impact adherence. Our results indicate that providing ART to all eligible HIV-infected members in a household is associated with excellent adherence in both parents and children. Adherence to ART among new parents declines over time, even when patients receive treatment at no cost. Depression should be addressed as a potential barrier to adherence. Further study is necessary to assess the long-term impact of this family treatment model on adherence to ART in resource-limited settings.

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Title: Longitudinal Antiretroviral Adherence in HIV+ Ugandan Parents and Their Children Initiating HAART in the MTCT-Plus Family Treatment Model: Role of Depression in Declining Adherence Over Time
Authors: Jayne Byakika-Tusiime
Johanna Crane
Jessica H. Oyugi
Kathleen Ragland
Annet Kawuma
Philippa Musoke
David R. Bangsberg
Publication date: 01-06-2009
Publisher: Springer US
Published in: AIDS and Behavior / Issue Special Issue 1/2009
Print ISSN: 1090-7165
Electronic ISSN: 1573-3254
DOI: https://doi.org/10.1007/s10461-009-9546-x

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Longitudinal Antiretroviral Adherence in HIV+ Ugandan Parents and Their Children Initiating HAART in the MTCT-Plus Family Treatment Model: Role of Depression in Declining Adherence Over Time

Abstract

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