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Magnetic Resonance Materials in Physics, Biology and Medicine
Published in: Magnetic Resonance Materials in Physics, Biology and Medicine 1/2022

Open Access 01-02-2022 | Radiotherapy | Review

A systematic review on the use of quantitative imaging to detect cancer therapy adverse effects in normal-appearing brain tissue

Authors: Jan Petr, Louise Hogeboom, Pavel Nikulin, Evita Wiegers, Gwen Schroyen, Jesper Kallehauge, Marek Chmelík, Patricia Clement, Ruben E. Nechifor, Liviu-Andrei Fodor, Philip C. De Witt Hamer, Frederik Barkhof, Cyril Pernet, Maarten Lequin, Sabine Deprez, Radim Jančálek, Henk J. M. M. Mutsaerts, Francesca B. Pizzini, Kyrre E. Emblem, Vera C. Keil

Published in: Magnetic Resonance Materials in Physics, Biology and Medicine | Issue 1/2022

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Abstract

Cancer therapy for both central nervous system (CNS) and non-CNS tumors has been previously associated with transient and long-term cognitive deterioration, commonly referred to as ‘chemo fog’. This therapy-related damage to otherwise normal-appearing brain tissue is reported using post-mortem neuropathological analysis. Although the literature on monitoring therapy effects on structural magnetic resonance imaging (MRI) is well established, such macroscopic structural changes appear relatively late and irreversible. Early quantitative MRI biomarkers of therapy-induced damage would potentially permit taking these treatment side effects into account, paving the way towards a more personalized treatment planning.
This systematic review (PROSPERO number 224196) provides an overview of quantitative tomographic imaging methods, potentially identifying the adverse side effects of cancer therapy in normal-appearing brain tissue. Seventy studies were obtained from the MEDLINE and Web of Science databases. Studies reporting changes in normal-appearing brain tissue using MRI, PET, or SPECT quantitative biomarkers, related to radio-, chemo-, immuno-, or hormone therapy for any kind of solid, cystic, or liquid tumor were included. The main findings of the reviewed studies were summarized, providing also the risk of bias of each study assessed using a modified QUADAS-2 tool. For each imaging method, this review provides the methodological background, and the benefits and shortcomings of each method from the imaging perspective. Finally, a set of recommendations is proposed to support future research.
Appendix
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Metadata
Title
A systematic review on the use of quantitative imaging to detect cancer therapy adverse effects in normal-appearing brain tissue
Authors
Jan Petr
Louise Hogeboom
Pavel Nikulin
Evita Wiegers
Gwen Schroyen
Jesper Kallehauge
Marek Chmelík
Patricia Clement
Ruben E. Nechifor
Liviu-Andrei Fodor
Philip C. De Witt Hamer
Frederik Barkhof
Cyril Pernet
Maarten Lequin
Sabine Deprez
Radim Jančálek
Henk J. M. M. Mutsaerts
Francesca B. Pizzini
Kyrre E. Emblem
Vera C. Keil
Publication date
01-02-2022
Publisher
Springer International Publishing
Published in
Magnetic Resonance Materials in Physics, Biology and Medicine / Issue 1/2022
Print ISSN: 0968-5243
Electronic ISSN: 1352-8661
DOI
https://doi.org/10.1007/s10334-021-00985-2

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