Top

Published in:

01-12-2024 | Radiotherapy | Case Report

Association of photobiomodulation and antimicrobial photodynamic therapy in healing after multiple extraction in head and neck post-radiotherapy- a case report and literature review

Authors: Ana Carolina Fechine Vidal, Yuri Lins dos Santos, Renally Leite da Silva, Diego Filipe Bezerra Silva, Rachel Cristina de Queiroz Pinheiro, Daliana Queiroga de Castro Gomes

Published in: Lasers in Dental Science | Issue 1/2024

Abstract

Purpose

To report a clinical case involving the use of photobiomodulation (PBMT) and antimicrobial photodynamic therapy (aPDT) in the management of delayed healing after multiple extractions in a patient irradiated in the head and neck region.

Case report

A 62-year-old male patient sought the service complaining of fractured teeth, difficulty chewing and aesthetic impairment. Ten years ago, he was diagnosed with infiltrative squamous cell carcinoma (SCC) on the tongue edge and underwent radiotherapy. The intraoral physical examination revealed caries and extensive bone resorption in the teeth 43, 42 and 33, and fracture of the crown of the tooth 34, thus, it was decided to perform their extraction. After the procedure, PBMT was performed on the entire sutured area with a wavelength of 660 nm, 0.5 J, for 5 s. Then, the buccal and lingual bone plates were irradiated, with a wavelength of 808 nm, 1 J, for 10 s, with the tip in contact with the tissue at both wavelengths. Associated with PBMT, aPDT was performed with 0.01% methylene blue, radiating with a wavelength of 660 nm and 4 J.

Conclusion

The PBMT associated with aPDT was an effective and safe modality, with no intercurrences in both surgeries, and the patient did not report pain or any discomfort in the postoperative period. The patient was rehabilitated with upper and lower total prosthesis, and has been proserved for 24 months, with no sign of bone necrosis, or any other alteration.

Wittekindt C, Wagner S, Sharma SJ, Würdemann N, Knuth J, Reder H, Klußmann JP (2018) HPV - a different view on head and neck cancer. Laryngorhinootologie 97(01):S48–S113. https://doi.org/10.1055/s-0043-121596CrossRefPubMedPubMedCentral

Olivares-Urbano MA, Griñán-Lisón C, Marchal JA, Núñez MI (2020) CSC radioresistance: a therapeutic challenge to improve radiotherapy effectiveness in cancer. Cells 9(7):1651. https://doi.org/10.3390/cells9071651CrossRefPubMedPubMedCentral

Deloch L, Derer A, Hartmann J, Frey B, Fietkau R, Gaipl US (2016) Modern radiotherapy concepts and the impact of radiation on immune activation. Front Oncol 20:6:141. https://doi.org/10.3389/fonc.2016.00141CrossRef

Kawashita Y, Soutome S, Umeda M, Saito T (2020) Oral management strategies for radiotherapy of head and neck cancer. Jpn Dent Sci Rev 56(1):62–67. https://doi.org/10.1016/j.jdsr.2020.02.001CrossRefPubMedPubMedCentral

Frankart AJ, Frankart MJ, Cervenka B, Tang AL, Krishnan DG, Takiar V (2021) Osteoradionecrosis: exposing the evidence not the bone. Int J Radiat Oncol Biol Phys 109(5):1206–1218. https://doi.org/10.1016/j.ijrobp.2020.12.043CrossRefPubMed

Palma LF, Marcucci M, Remondes CM, Chambrone L (2021) Antibiotic therapy for the prevention of osteoradionecrosis following tooth extraction in head-and-neck cancer patients post radiotherapy: an 11-year retrospective study. Natl J Maxillofac Surg 12(3):333–338. https://doi.org/10.4103/njms.njms_413_21CrossRefPubMedPubMedCentral

Reuther T, Schuster T, Mende U, Kübler A (2003) Osteoradionecrosis of the jaws as a side effect of radiotherapy of head and neck tumour patients–a report of a thirty year retrospective review. Int J Oral Maxillofac Surg 32(3):289–295. https://doi.org/10.1054/ijom.2002.0332CrossRefPubMed

El-Rabbany M, Duchnay M, Raziee HR, Zych M, Tenenbaum H, Shah PS, Azarpazhooh A (2019) Interventions for preventing osteoradionecrosis of the jaws in adults receiving head and neck radiotherapy. Cochrane Database Syst Rev 20(11):CD011559. https://doi.org/10.1002/14651858.CD011559.pub2CrossRef

Ribeiro GH, Minamisako MC, Rath IBDS, Santos AMB, Simões A, Pereira KCR, Grando LJ (2018) Osteoradionecrosis of the jaws: case series treated with adjuvant low-level laser therapy and antimicrobial photodynamic therapy. J Appl Oral Sci 26:e20170172. https://doi.org/10.1590/1678-7757-2017-0172CrossRefPubMedPubMedCentral

10.

Tateno RY, Palma LF, Sendyk WR, Campos L (2020) Laser and antimicrobial photodynamic therapy for the management of delayed healing following multiple dental extractions in a post-radiotherapy patient. Photodiagnosis Photodyn Ther 30:101764. https://doi.org/10.1016/j.pdpdt.2020.101764CrossRefPubMed

11.

Pires Marques EC, Piccolo Lopes F, Nascimento IC, Morelli J, Pereira MV, Machado Meiken VM, Pinheiro SL (2020) Photobiomodulation and photodynamic therapy for the treatment of oral mucositis in patients with cancer. Photodiagnosis Photodyn Ther 29:101621. https://doi.org/10.1016/j.pdpdt.2019.101621CrossRefPubMed

12.

Peralta-Mamani M, da Silva BM, da Silva Pinto AC, Rubira-Bullen IRF, Honório HM, Rubira CMF, da Silva Santos OS (2019) Low-level laser therapy dosimetry most used for oral mucositis due to radiotherapy for head and neck cancer: a systematic review and meta-analysis. Crit Rev Oncol Hematol 138:14–23. https://doi.org/10.1016/j.critrevonc.2019.03.009CrossRefPubMed

13.

da Silva TMV, Melo TS, de Alencar RC, Pereira JRD, Leão JC, Silva IHM, Gueiros LA (2021) Photobiomodulation for mucosal repair in patients submitted to dental extraction after head and neck radiation therapy: a double-blind randomized pilot study. Support Care Cancer 29(3):1347–1354. https://doi.org/10.1007/s00520-020-05608-5CrossRefPubMed

14.

Sperandio FF et al (2015) Antimicrobial photodynamic therapy in dentistry. In: Lasers in Dentistry: Guide for Clinical Practice 1 ed. Wiley-Blackwell, 2015. cap. 7, 40–47

15.

Ozog DM, Rkein AM, Fabi SG, Gold MH, Goldman MP, Lowe NJ, Martin GM, Munavalli GS (2016) Photodynamic therapy: a clinical consensus guide. Dermatol Surg 42(7):804–827. https://doi.org/10.1097/DSS.0000000000000800CrossRefPubMed

16.

Cheriex KC, Nijhuis TH, Mureau MA (2012) Osteoradionecrosis of the jaws: a review of conservative and surgical treatment options. J Reconstr Microsurg 29(2):69–75. https://doi.org/10.1055/s-0032-1329923CrossRefPubMed

17.

Dutheil F, Guillemin F, Biau J, Pham-Dang N, Saroul N, Clavère P, Lapeyre M (2021) Facteurs prédictifs de l’ostéoradionécrose mandibulaire après irradiation Des cancers des voies aérodigestives supérieures [Predictive factors for mandibular osteoradionecrosis after irradiation of head and neck cancers]. Cancer Radiother 25(5):484–493. https://doi.org/10.1016/j.canrad.2021.03.002CrossRefPubMed

18.

Nabil S, Samman N (2011) Incidence and prevention of osteoradionecrosis after dental extraction in irradiated patients: a systematic review. Int J Oral Maxillofac Surg 40(3):229–243. https://doi.org/10.1016/j.ijom.2010.10.005CrossRefPubMed

19.

De Felice F, Musio D, Tombolini V (2016) Osteoradionecrosis and intensity modulated radiation therapy: an overview. Crit Rev Oncol Hematol 107:39–43. https://doi.org/10.1016/j.critrevonc.2016.08.017CrossRefPubMed

20.

Oyama J, Fernandes Herculano Ramos-Milaré ÁC, Lopes Lera-Nonose DSS, Nesi-Reis V, Galhardo Demarchi I, Alessi Aristides SM, Juarez Vieira Teixeira J et al (2020) Photodynamic therapy in wound healing in vivo: a systematic review. Photodiagnosis Photodyn Ther 30:101682. https://doi.org/10.1016/j.pdpdt.2020.101682CrossRefPubMed

21.

Pedroni ACF, Miniello TG, Hirota C, Carvalho MH, Lascala CA, Marques MM (2020) Successful application of antimicrobial photodynamic and photobiomodulation therapies for controlling osteoradionecrosis and xerostomia after laryngeal carcinoma treatment: a case report of full oral rehabilitation. Photodiagnosis Photodyn Ther 31:101835. https://doi.org/10.1016/j.pdpdt.2020.101835CrossRefPubMed

22.

Magalhães IA, Forte CPF, Viana TSA, Teófilo CR, Lima Verde RMB, Magalhães DP et al (2020) Photobiomodulation and antimicrobial photodynamic therapy as adjunct in the treatment and prevention of osteoradionecrosis of the jaws: a case report. Photodiagnosis Photodyn Ther 31:101959. https://doi.org/10.1016/j.pdpdt.2020.101959CrossRefPubMed

Title: Association of photobiomodulation and antimicrobial photodynamic therapy in healing after multiple extraction in head and neck post-radiotherapy- a case report and literature review
Authors: Ana Carolina Fechine Vidal
Yuri Lins dos Santos
Renally Leite da Silva
Diego Filipe Bezerra Silva
Rachel Cristina de Queiroz Pinheiro
Daliana Queiroga de Castro Gomes
Publication date: 01-12-2024
Publisher: Springer International Publishing
Keywords: Radiotherapy
Photodynamic Therapy
Tooth Extraction
Tooth Extraction
Laser
Published in: Lasers in Dental Science / Issue 1/2024
Electronic ISSN: 2367-2587
DOI: https://doi.org/10.1007/s41547-024-00239-z

At a glance: The STEP trials

Springer Medicine

Association of photobiomodulation and antimicrobial photodynamic therapy in healing after multiple extraction in head and neck post-radiotherapy- a case report and literature review

Abstract

Purpose

Case report

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Case report

Conclusion

Please log in to get access to this content

Other articles of this Issue 1/2024

Correction to: Evaluating the efficiency of Er,Cr:YSGG laser for recycling of debonded stainless steel orthodontic brackets: an in vitro study

Correction to: Effect of femtosecond and ER:YAG laser systems on shear bond strength of enamel surface and morphological changes

Morphological changes in periodontopathic bacteria after Er,Cr:YSGG laser irradiation

Correction to: High power diode laser in the treatment of pyogenic granuloma in young patients

Temperature rise on external root surface during 810- and 970-nm diode laser application in endodontic treatments

The effectiveness of low level laser therapy and ibuprofen in the management of pain during orthodontics treatments: a meta-analysis of meta-analyses