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Journal of Translational Medicine
Published in: Journal of Translational Medicine 1/2021

Open Access 01-12-2021 | Radiotherapy | Review

GSTP1 as a novel target in radiation induced lung injury

Authors: Xiao Lei, Lehui Du, Wei Yu, Yao Wang, Na Ma, Baolin Qu

Published in: Journal of Translational Medicine | Issue 1/2021

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Abstract

The glutathione S-transferase P1(GSTP1) is an isoenzyme in the glutathione-S transferases (GSTs) enzyme system, which is the most abundant GSTs expressed in adult lungs. Recent research shows that GSTP1 is closely related to the regulation of cell oxidative stress, inhibition of cell apoptosis and promotion of cytotoxic metabolism. Interestingly, there is evidence that GSTP1 single nucleotide polymorphisms (SNP) 105Ile/Val related to the risk of radiation induced lung injury (RILI) development, which strongly suggests that GSTP1 is closely associated with the occurrence and development of RILI. In this review, we discuss our understanding of the role of GSTP1 in RILI and its possible mechanism.
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Metadata
Title
GSTP1 as a novel target in radiation induced lung injury
Authors
Xiao Lei
Lehui Du
Wei Yu
Yao Wang
Na Ma
Baolin Qu
Publication date
01-12-2021
Publisher
BioMed Central
Keyword
Radiotherapy
Published in
Journal of Translational Medicine / Issue 1/2021
Electronic ISSN: 1479-5876
DOI
https://doi.org/10.1186/s12967-021-02978-0

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