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Clinical Oral Investigations
Published in: Clinical Oral Investigations 6/2021

01-06-2021 | Radiotherapy | Original Article

Clinical applicability of natural products for prevention and treatment of oral mucositis: a systematic review and meta-analysis

Authors: Ingrid Carla Guedes da Silva Lima, Laura de Fátima Souto Maior, Luiz Alcino Monteiro Gueiros, Jair Carneiro Leão, Jane Sheila Higino, Alessandra Albuquerque Tavares Carvalho

Published in: Clinical Oral Investigations | Issue 6/2021

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Abstract

Objective

A systematic review and meta-analysis was carried out to verify evidence regarding the efficacy and safety of the clinical applicability of natural products in the prevention and treatment of oral mucositis induced by chemotherapy and/or radiotherapy.

Methodology

An electronic research according to the PICOS strategy, using the terms “natural products” and “oral mucositis,” was carried out at Pubmed, Cochrane, Embase, and “gray literature.” The stages of eligibility, data extraction, and quality assessment of the studies were carried out independently and in duplicate.

Results

The number of studies identified as eligible was 151, including 47 randomized controlled trials, reporting a total of 3075 participants undergoing some therapy with natural products on oral mucositis. The included clinical trials covered a variety of 31 types of natural products. Considering the risk of bias of the clinical trials, 24 studies (51.1%) were considered to have a low overall risk of bias, nine (19.1%) were at moderate risk, and 14 clinical trials (29.8%) were at high risk of bias. Honey was the most assessed natural agent. Fourteen studies (3.4%) reported that natural agents reduced pain.

Conclusion

The results of the meta-analysis support a positive effect of honey and Aloe vera in reducing mucositis in patients receiving cancer therapy.

Clinical relevance

The results found add relevant information to the scientific community regarding the prevention and treatment of mucositis.
Graphical abstract
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Metadata
Title
Clinical applicability of natural products for prevention and treatment of oral mucositis: a systematic review and meta-analysis
Authors
Ingrid Carla Guedes da Silva Lima
Laura de Fátima Souto Maior
Luiz Alcino Monteiro Gueiros
Jair Carneiro Leão
Jane Sheila Higino
Alessandra Albuquerque Tavares Carvalho
Publication date
01-06-2021
Publisher
Springer Berlin Heidelberg
Published in
Clinical Oral Investigations / Issue 6/2021
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI
https://doi.org/10.1007/s00784-020-03743-1

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