Published in:
Open Access
01-12-2018 | Letter to the Editor
Pulmonary aspiration in preschool children with cystic fibrosis
Authors:
D. Clarke, I. Gorman, F. Ringholz, M. McDermott, DW. Cox, P. Greally, B. Linnane, P. Mc Nally
Published in:
Respiratory Research
|
Issue 1/2018
Login to get access
Abstract
Pulmonary aspiration of gastric refluxate (PAGR) has been demonstrated in association with pulmonary inflammation in school aged children with Cystic Fibrosis (CF). We sought to determine if similar findings were present in preschool children. Pepsin was measured in Broncho-alveolar lavage (BAL) fluid collected from clinically stable preschool children with CF and controls. Elevated pepsin levels were found in a subgroup of children with CF, but this was not found to be associated with pulmonary infection, pulmonary inflammation or respiratory or gastrointestinal symptoms.