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Respiratory Research
Published in: Respiratory Research 1/2018

Open Access 01-12-2018 | Review

Macrophages: friend or foe in idiopathic pulmonary fibrosis?

Authors: Lei Zhang, Yi Wang, Guorao Wu, Weining Xiong, Weikuan Gu, Cong-Yi Wang

Published in: Respiratory Research | Issue 1/2018

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Abstract

Idiopathic pulmonary fibrosis (IPF) is a prototype of lethal, chronic, progressive interstitial lung disease of unknown etiology. Over the past decade, macrophage has been recognized to play a significant role in IPF pathogenesis. Depending on the local microenvironments, macrophages can be polarized to either classically activated (M1) or alternatively activated (M2) phenotypes. In general, M1 macrophages are responsible for wound healing after alveolar epithelial injury, while M2 macrophages are designated to resolve wound healing processes or terminate inflammatory responses in the lung. IPF is a pathological consequence resulted from altered wound healing in response to persistent lung injury. In this review, we intend to summarize the current state of knowledge regarding the process of macrophage polarization and its mediators in the pathogenesis of pulmonary fibrosis. Our goal is to update the understanding of the mechanisms underlying the initiation and progression of IPF, and by which, we expect to provide help for developing effective therapeutic strategies in clinical settings.
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Metadata
Title
Macrophages: friend or foe in idiopathic pulmonary fibrosis?
Authors
Lei Zhang
Yi Wang
Guorao Wu
Weining Xiong
Weikuan Gu
Cong-Yi Wang
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Respiratory Research / Issue 1/2018
Electronic ISSN: 1465-993X
DOI
https://doi.org/10.1186/s12931-018-0864-2

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