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Open Access 01-12-2022 | Pruritus | Study protocol

Effects of photobiomodulation on re-epithelialization of burn wound: protocol for a randomized controlled trial

Authors: Silvana Cristina de Araújo Pereira Venceslau, Júlia Lacet Silva Ferreira, Renata Maria Freire Barros, Ronny Marcos de Morais, Heleodório Honorato dos Santos, Valéria Mayaly Alves de Oliveira, Palloma Rodrigues de Andrade

Published in: Trials | Issue 1/2022

Abstract

Background

Burns are a global public health problem and cause approximately 180,000 deaths annually, mainly in low- and middle-income countries. Topical antibiotics and occlusive dressing are standard treatments for burns not requiring a skin graft. However, physiotherapy has low-cost phototherapeutic and electrophysical resources (e.g., light-emitting diode [LED]) that may accelerate burn healing. This study aims to compare the re-epithelialization rate of second-degree burns, pain, pruritus, skin temperature, quality of wound healing, and scar quality and mobility among individuals undergoing treatment with red LED, infrared LED, and simulated photobiomodulation.

Methods

This is a double-blinded, three-arm parallel-group, randomized controlled superiority trial. Individuals of both sexes, aged over 18 years, and with second-degree burns will be included. The sample will be divided into three groups of 13 individuals: two will receive LED therapy (red or infrared) and one placebo. Pain, pruritus, skin temperature, and wound size will be assessed daily. Interventions will take place until complete healing, when scar mobility and quality will be evaluated. Data will be presented as mean and 95% confidence interval and analyzed using mixed linear models.

Discussion

This randomized controlled trial has minimal risk of bias and intends to identify the ideal type, procedures, and doses of photobiomodulation to heal burns, which are not standardized in clinical practice. Positive results will allow the implementation of the technique in burn and wound guidelines.

Trial registration

Brazilian Clinical Trials Registry (ReBEC) RBR-8bfznx6. Registered on October 13, 2021

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Title: Effects of photobiomodulation on re-epithelialization of burn wound: protocol for a randomized controlled trial
Authors: Silvana Cristina de Araújo Pereira Venceslau
Júlia Lacet Silva Ferreira
Renata Maria Freire Barros
Ronny Marcos de Morais
Heleodório Honorato dos Santos
Valéria Mayaly Alves de Oliveira
Palloma Rodrigues de Andrade
Publication date: 01-12-2022
Publisher: BioMed Central
Keyword: Pruritus
Published in: Trials / Issue 1/2022
Electronic ISSN: 1745-6215
DOI: https://doi.org/10.1186/s13063-022-06505-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Effects of photobiomodulation on re-epithelialization of burn wound: protocol for a randomized controlled trial

Abstract

Background

Methods

Discussion

Trial registration

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Discussion

Trial registration

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