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01-10-2013 | Musculoskeletal

Proton magnetic resonance spectroscopy in the evaluation of patients with acute Charcot neuro-osteoarthropathy

Authors: Francesca Bolacchi, Luigi Uccioli, Salvatore Masala, Laura Giurato, Valeria Ruotolo, Marco Meloni, Eleonora Baffari, Elenia Cinelli, Marcello Cadioli, Ettore Squillaci, Giovanni Simonetti, Alberto Bergamini

Published in: European Radiology | Issue 10/2013

Abstract

Objective

To evaluate whether bone marrow proton magnetic resonance spectroscopy (MRS) might provide a quantitative parameter able to assess disease activity in acute Charcot neuro-osteoarthropathy (CN).

Methods

Ten diabetic patients with stage 0 CN were prospectively evaluated at clinical onset and during treatment follow-up. The MRS lipid spectrum was analysed and a lipid polyunsaturation index (PUI) was calculated. Disease recovery was defined as the disappearance of bone marrow oedema as demonstrated on MRI short-tau-inversion-recovery (STIR) images. A 3-T MRI was used.

Results

Inter- and intra-individual PUI measurements generated reproducible results with approximately 7 % and 6 % variation respectively. Baseline PUI values were significantly higher in patients with acute CN compared with controls. Also, a significant positive correlation was observed between baseline PUI values and serum levels of IL-6 and TNF-α. During follow-up a gradual decrease in PUI was observed. The percentage reduction of PUI values at 3 months’ follow-up with respect to baseline values showed a negative correlation with recovery time.

Conclusions

Bone marrow MRS may provide a measurable index that allows progressive evaluation of disease activity in acute CN. MRS may be a complementary tool that can be used to guide clinicians in the management of acute CN patients.

Key Points

• Bone marrow MRS demonstrates lipid alterations in acute Charcot neuro-osteoarthropathy (CN).

• Bone marrow MRS allows disease activity in acute CN to be evaluated.

• MRS could become a new tool in the management of CN.

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Title: Proton magnetic resonance spectroscopy in the evaluation of patients with acute Charcot neuro-osteoarthropathy
Authors: Francesca Bolacchi
Luigi Uccioli
Salvatore Masala
Laura Giurato
Valeria Ruotolo
Marco Meloni
Eleonora Baffari
Elenia Cinelli
Marcello Cadioli
Ettore Squillaci
Giovanni Simonetti
Alberto Bergamini
Publication date: 01-10-2013
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 10/2013
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-013-2894-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Proton magnetic resonance spectroscopy in the evaluation of patients with acute Charcot neuro-osteoarthropathy

Abstract

Objective

Methods

Results

Conclusions

Key Points

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Methods

Results

Conclusions

Key Points

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