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Archives of Virology
Published in: Archives of Virology 5/2010

01-05-2010 | Brief Report

Protein kinase C-dependent phosphorylation of Borna disease virus P protein is required for efficient viral spread

Authors: Sonja Schmid, Philippe Metz, Christine M. A. Prat, Daniel Gonzalez-Dunia, Martin Schwemmle

Published in: Archives of Virology | Issue 5/2010

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Abstract

Mutational analysis of the phosphate acceptor sites of the Borna disease virus (BDV) phosphoprotein (P) has suggested a role of phosphorylation for viral spread. However, the studied mutant viruses also had two amino acid exchanges in the X protein, because the reading frames of P and X overlap. To determine the relative contribution of P and X to viral attenuation, we studied a P variant with serine-to-leucine substitutions (PS26L,S28L) in which the wild-type X sequence was conserved. Viral spread of rBDV-PS26L,S28L was impaired in human oligodendroglioma cells and in adult rats. Thus, BDV-P phosphorylation contributes to efficient viral dissemination.
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Metadata
Title
Protein kinase C-dependent phosphorylation of Borna disease virus P protein is required for efficient viral spread
Authors
Sonja Schmid
Philippe Metz
Christine M. A. Prat
Daniel Gonzalez-Dunia
Martin Schwemmle
Publication date
01-05-2010
Publisher
Springer Vienna
Published in
Archives of Virology / Issue 5/2010
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI
https://doi.org/10.1007/s00705-010-0645-9

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