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Archives of Virology
Published in: Archives of Virology 5/2010

01-05-2010 | Brief Report

Protection against HIV-envelope-induced neuronal cell destruction by HIV attachment inhibitors

Authors: Sharon Zhang, Louis Alexander, Tao Wang, Michele Agler, Nannon Zhou, Hua Fang, John Kadow, Paul Clapham, Pin-Fang Lin

Published in: Archives of Virology | Issue 5/2010

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Abstract

We demonstrate that HIV attachment inhibitors (AIs) prevent HIV envelope-induced destruction of two neuronal cell lines (SH-SY5Y and BE(2)-M17) at low nanomolar concentrations. The fusion inhibitor enfuvirtide and the CCR5 inhibitors UK427,857 and TAK779 do not display protection activity, suggesting the involvement of Env/cell interaction site(s) distinct from the sites involved in the viral entry process. We surmise that by inducing conformation changes in the envelope, AIs likely obstruct novel interactions with a neuronal cell factor(s) required for induction of apoptosis. This antiretroviral class may therefore have the potential to inhibit HIV-induced neuron damage, thereby curtailing the increasing incidence of HIV-associated cognitive impairment.
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Metadata
Title
Protection against HIV-envelope-induced neuronal cell destruction by HIV attachment inhibitors
Authors
Sharon Zhang
Louis Alexander
Tao Wang
Michele Agler
Nannon Zhou
Hua Fang
John Kadow
Paul Clapham
Pin-Fang Lin
Publication date
01-05-2010
Publisher
Springer Vienna
Published in
Archives of Virology / Issue 5/2010
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI
https://doi.org/10.1007/s00705-010-0644-x

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Keynote webinar | Spotlight on medication adherence

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WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

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