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Medical Microbiology and Immunology
Published in: Medical Microbiology and Immunology 4/2012

01-11-2012 | Review

Principles of polyoma- and papillomavirus uncoating

Authors: Carla Cerqueira, Mario Schelhaas

Published in: Medical Microbiology and Immunology | Issue 4/2012

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Abstract

Virus particles are vehicles for transmission of the viral genetic information between infected and uninfected cells and organisms. They have evolved to self-assemble, to serve as a protective shell for the viral genome during transfer, and to disassemble when entering a target cell. Disassembly during entry is a complex, multi-step process typically termed uncoating. Uncoating is triggered by multiple host-cell interactions. During cell entry, these interactions occur sequentially in different cellular compartments that the viruses pass through on their way to the site of replication. Here, we highlight the general principles of uncoating for two structurally related virus families, the polyoma- and papillomaviruses. Recent research indicates the use of different compartments and cellular interactions for uncoating despite their structural similarity.
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Metadata
Title
Principles of polyoma- and papillomavirus uncoating
Authors
Carla Cerqueira
Mario Schelhaas
Publication date
01-11-2012
Publisher
Springer-Verlag
Published in
Medical Microbiology and Immunology / Issue 4/2012
Print ISSN: 0300-8584
Electronic ISSN: 1432-1831
DOI
https://doi.org/10.1007/s00430-012-0262-1

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