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World Journal of Surgical Oncology

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Open Access 01-12-2008 | Case report

Primary Kaposi sarcoma of the subcutaneous tissue

Authors: Liron Pantanowitz, John Mullen, Bruce J Dezube

Published in: World Journal of Surgical Oncology | Issue 1/2008

Abstract

Background

Involvement of the subcutis by Kaposi sarcoma (KS) occurs primarily when cutaneous KS lesions evolve into deep penetrating nodular tumors. Primary KS of the subcutaneous tissue is an exceptional manifestation of this low-grade vascular neoplasm.

Case presentation

We present a unique case of acquired immune deficiency syndrome (AIDS)-associated KS manifesting primarily in the subcutaneous tissue of the anterior thigh in a 43-year-old male, which occurred without overlying visible skin changes or concomitant KS disease elsewhere. Radiological imaging and tissue biopsy confirmed the diagnosis of KS.

Conclusion

This is the first documented case of primary subcutaneous KS occurring in the setting of AIDS. The differential diagnosis of an isolated subcutaneous lesion in an human immunodeficiency virus (HIV)-infected individual is broad, and requires both imaging and a histopathological diagnosis to guide appropriate therapy.

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Pantanowitz L, Dezube BJ: Kaposi sarcoma in unusual anatomical locations. BMC Cancer. 2008, 8: 190-10.1186/1471-2407-8-190.PubMedCentralCrossRefPubMed

Caponetti G, Dezube BJ, Restrepo CS, Pantanowitz L: Kaposi sarcoma of the musculoskeletal system. A review of 66 patients. Cancer. 2007, 109: 1040-1052. 10.1002/cncr.22500.CrossRefPubMed

Lee VW, Chen H, Panageas E, O'Keane JC, Liebman HA: Subcutaneous Kaposi's sarcoma. Thallium scan demonstration. Clin Nucl Med. 1990, 15: 569-571. 10.1097/00003072-199008000-00011.CrossRefPubMed

Bossuyt L, Oord Van den JJ, Degreef H: Lymphangioma-like variant of AIDS-associated Kaposi's sarcoma with pronounced edema formation. Dermatology. 1995, 190: 324-326.CrossRefPubMed

Corti M, Villafañe MF, Ambroggi M, Sawicki M, Gancedo E: Soft tissue abscess and lymphadenitis due to Mycobacterium avium complex as an expression of immune reconstitution inflammatory syndrome after a second scheme of highly active antiretroviral therapy. Rev Inst Med Trop Sao Paulo. 2007, 49: 267-270.CrossRefPubMed

Balestreire E, Haught JM, English JC: Multiple subcutaneous lipomas induced by HAART in the absence of protease inhibitors. Arch Dermatol. 2007, 143: 1596-1597. 10.1001/archderm.143.12.1596.CrossRefPubMed

Jenson HB, Leach CT, McClain KL, Joshi VV, Pollock BH, Parmley RT, Chadwick EG, Murphy SB: Benign and malignant smooth muscle tumors containing Epstein-Barr virus in children with AIDS. Leuk Lymphoma. 1997, 27: 303-314.PubMed

Suankratay C, Shuangshoti S, Mutirangura A, Prasanthai V, Lerdlum S, Shuangshoti S, Pintong J, Wilde H: Epstein-Barr virus infection-associated smooth-muscle tumors in patients with AIDS. Clin Infect Dis. 2005, 40: 1521-1528. 10.1086/429830.CrossRefPubMed

Haddow LJ, Davies S, Buckingham S, Miller RF: Kaposi's sarcoma infiltrating skeletal muscle. Sex Transm Infect. 2002, 78: 464-465. 10.1136/sti.78.6.464.PubMedCentralCrossRefPubMed

10.

Douglas JL, Gustin JK, Dezube B, Pantanowitz JL, Moses AV: Kaposi's sarcoma: a model of both malignancy and chronic inflammation. Panminerva Med. 2007, 49: 119-138.PubMed

11.

Cheung L, Rockson SG: The lymphatic biology of Kaposi's sarcoma. Lymphat Res Biol. 2005, 3: 25-35. 10.1089/lrb.2005.3.25.CrossRefPubMed

12.

Ruocco V, Schwartz RA, Ruocco E: Lymphedema: an immunologically vulnerable site for development of neoplasms. J Am Acad Dermatol. 2002, 47: 124-127. 10.1067/mjd.2002.120909.CrossRefPubMed

13.

Webster-Cyriaque J: Development of Kaposi's sarcoma in a surgical wound. N Engl J Med. 2002, 346: 1207-1210. 10.1056/NEJMoa012125.CrossRefPubMed

14.

Micali G, Gasparri O, Nasca MR, Sapuppo A: Kaposi's sarcoma occurring de novo in the surgical scar in a heart transplant recipient. J Am Acad Dermatol. 1992, 27: 273-274.CrossRefPubMed

15.

Restrepo CS, Lemos DF, Gordillo H, Odero R, Varghese T, Tiemann W, Rivas FF, Moncada R, Gimenez CR: Imaging findings in musculoskeletal complications of AIDS. Radiographics. 2004, 24: 1029-1049. 10.1148/rg.244035151.CrossRefPubMed

16.

Restrepo CS, Martínez S, Lemos JA, Carrillo JA, Lemos DF, Ojeda P, Koshy P: Imaging manifestations of Kaposi sarcoma. Radiographics. 2006, 26: 1169-1185. 10.1148/rg.264055129.CrossRefPubMed

17.

Di Lorenzo G, Konstantinopoulos PA, Pantanowitz L, Di Trolio R, De Placido S, Dezube BJ: Management of AIDS-related Kaposi's sarcoma. Lancet Oncol. 2007, 8: 167-176. 10.1016/S1470-2045(07)70036-0.CrossRefPubMed

Title: Primary Kaposi sarcoma of the subcutaneous tissue
Authors: Liron Pantanowitz
John Mullen
Bruce J Dezube
Publication date: 01-12-2008
Publisher: BioMed Central
Published in: World Journal of Surgical Oncology / Issue 1/2008
Electronic ISSN: 1477-7819
DOI: https://doi.org/10.1186/1477-7819-6-94

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Primary Kaposi sarcoma of the subcutaneous tissue

Abstract

Background

Case presentation

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Case presentation

Conclusion

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