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Diagnostic Pathology
Published in: Diagnostic Pathology 1/2014

Open Access 01-12-2014 | Case Report

Primary extranodal NK/T cell lymphoma, nasal-type of uterus with adenomyosis: a case report

Authors: Jian-chen Fang, Jue Zhou, Zheng Li, Zhao-xia Xia

Published in: Diagnostic Pathology | Issue 1/2014

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Abstract

Natural killer (NK)/T cell lymphoma of the female genital tract is extremely rare. We here report a case of ‘nasal type’ NK/T cell lymphoma arising in the uterus with adenomyosis in a 41-year-old woman with fever and hypogastralgia. The histologic analysis demonstrated a highly aggressive tumor with characteristic angiocentric/angiodestructive growth pattern and focal necrosis. The lymphoma cells displayed a CD3ϵ/CD56/TIA-1/granzyme-B/Perforin-positive and CD20/CD79a/CD4/CD8-negative immunophenotype and positive for Epstein-Barr virus by EBER in situ hybridization. Clinically, the disease was limited to the uterus at the initial diagnosis, but progressed rapidly. The patient died on day 54 after hysterectomy, irrespective of intensive chemotherapy.

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Metadata
Title
Primary extranodal NK/T cell lymphoma, nasal-type of uterus with adenomyosis: a case report
Authors
Jian-chen Fang
Jue Zhou
Zheng Li
Zhao-xia Xia
Publication date
01-12-2014
Publisher
BioMed Central
Published in
Diagnostic Pathology / Issue 1/2014
Electronic ISSN: 1746-1596
DOI
https://doi.org/10.1186/1746-1596-9-95

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