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BMC Neurology
Published in: BMC Neurology 1/2024

Open Access 01-12-2024 | Positron Emission Tomography | Study Protocol

Updating the study protocol: Insight 46 – a longitudinal neuroscience sub-study of the MRC National Survey of Health and Development – phases 2 and 3

Authors: Heidi Murray-Smith, Suzie Barker, Frederik Barkhof, Josephine Barnes, Thomas M. Brown, Gabriella Captur, Molly R.E.Cartlidge, David M. Cash, William Coath, Daniel Davis, John C. Dickson, James Groves, Alun D. Hughes, Sarah-Naomi James, Ashvini Keshavan, Sarah E. Keuss, Josh King-Robson, Kirsty Lu, Ian B. Malone, Jennifer M. Nicholas, Alicja Rapala, Catherine J. Scott, Rebecca Street, Carole H. Sudre, David L. Thomas, Andrew Wong, Selina Wray, Henrik Zetterberg, Nishi Chaturvedi, Nick C. Fox, Sebastian J. Crutch, Marcus Richards, Jonathan M. Schott

Published in: BMC Neurology | Issue 1/2024

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Abstract

Background

Although age is the biggest known risk factor for dementia, there remains uncertainty about other factors over the life course that contribute to a person’s risk for cognitive decline later in life. Furthermore, the pathological processes leading to dementia are not fully understood. The main goals of Insight 46—a multi-phase longitudinal observational study—are to collect detailed cognitive, neurological, physical, cardiovascular, and sensory data; to combine those data with genetic and life-course information collected from the MRC National Survey of Health and Development (NSHD; 1946 British birth cohort); and thereby contribute to a better understanding of healthy ageing and dementia.

Methods/Design

Phase 1 of Insight 46 (2015–2018) involved the recruitment of 502 members of the NSHD (median age = 70.7 years; 49% female) and has been described in detail by Lane and Parker et al. 2017. The present paper describes phase 2 (2018–2021) and phase 3 (2021–ongoing). Of the 502 phase 1 study members who were invited to a phase 2 research visit, 413 were willing to return for a clinic visit in London and 29 participated in a remote research assessment due to COVID-19 restrictions. Phase 3 aims to recruit 250 study members who previously participated in both phases 1 and 2 of Insight 46 (providing a third data time point) and 500 additional members of the NSHD who have not previously participated in Insight 46.

Discussion

The NSHD is the oldest and longest continuously running British birth cohort. Members of the NSHD are now at a critical point in their lives for us to investigate successful ageing and key age-related brain morbidities. Data collected from Insight 46 have the potential to greatly contribute to and impact the field of healthy ageing and dementia by combining unique life course data with longitudinal multiparametric clinical, imaging, and biomarker measurements. Further protocol enhancements are planned, including in-home sleep measurements and the engagement of participants through remote online cognitive testing. Data collected are and will continue to be made available to the scientific community.
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Metadata
Title
Updating the study protocol: Insight 46 – a longitudinal neuroscience sub-study of the MRC National Survey of Health and Development – phases 2 and 3
Authors
Heidi Murray-Smith
Suzie Barker
Frederik Barkhof
Josephine Barnes
Thomas M. Brown
Gabriella Captur
Molly R.E.Cartlidge
David M. Cash
William Coath
Daniel Davis
John C. Dickson
James Groves
Alun D. Hughes
Sarah-Naomi James
Ashvini Keshavan
Sarah E. Keuss
Josh King-Robson
Kirsty Lu
Ian B. Malone
Jennifer M. Nicholas
Alicja Rapala
Catherine J. Scott
Rebecca Street
Carole H. Sudre
David L. Thomas
Andrew Wong
Selina Wray
Henrik Zetterberg
Nishi Chaturvedi
Nick C. Fox
Sebastian J. Crutch
Marcus Richards
Jonathan M. Schott
Publication date
01-12-2024
Publisher
BioMed Central
Published in
BMC Neurology / Issue 1/2024
Electronic ISSN: 1471-2377
DOI
https://doi.org/10.1186/s12883-023-03465-3

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